| 环磷酰胺治疗小鼠S180肉瘤的体内31P磁共振波谱研究 |
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| 引用本文： | 田建广,魏昌华,冯锐,李光玉,茹祥斌,杜泽涵.环磷酰胺治疗小鼠S180肉瘤的体内31P磁共振波谱研究[J].癌症,1999,18(3):285-287. |
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| 作者姓名： | 田建广 魏昌华 冯锐 李光玉 茹祥斌 杜泽涵 |
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| 作者单位： | 1. 军事医学科学院国家生物医学分析中心,北京,100850
2. 军事医学科学院毒物药物研究所 |
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| 摘 要： | 目的 观察环磷酰治疗小鼠Ｓ１８０肉瘤的＾３１ＰＭＲＳ参数变化，以及这些参数的变化是否早于常规观察的瘤体积变化。方法 利用表面线圈＾３１ＰＮＭＲ方法，并研究了小鼠皮下接种Ｓ１８０肉瘤的体积。结果：对照组的ＰＣｒ／Ｐｉ和＋β－ＮＴＰ／Ｐｉ比值降低，而环磷酰胺给药组升高，且给药后２４，４８，７２ｈ时显著高于对照组（Ｐ〈０．０５），对照组的ＰＭＥ／β－ＮＴＰ比值继续升高，而给药组ＰＭＥ／β－ＮＴＰ比值在给
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| 关 键 词： | 环磷酰胺 S180肉瘤 表面线圈 小鼠 |
In vivo studies of cyclophosphamide chemotherapy on mouse S180 sarcoma by 31P magnetic resonance spectroscopy |
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| TIAN Jianguang,WEI Changhua,FENG Rui,et al National
Center for Biomedical Analysis, Instiute of Pharmacology and Toxicology,Academy of Military
Sciences,Beijing ,China.In vivo studies of cyclophosphamide chemotherapy on mouse S180 sarcoma by 31P magnetic resonance spectroscopy[J].Chinese Journal of Cancer,1999,18(3):285-287. |
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| Authors: | TIAN Jianguang WEI Changhua FENG Rui National
Center for Biomedical Analysis Instiute of Pharmacology and Toxicology Academy of Military
Sciences Beijing China |
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| Institution: | TIAN Jianguang1,WEI Changhua2,FENG Rui1,et al 1 National
Center for Biomedical Analysis,2 Instiute of Pharmacology and Toxicology,Academy of Military
Sciences,Beijing 100850,China |
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| Abstract: | Objective: To investigate the effect of
cyclophosphamide (CTX) on the metabolic profile of mouse S180 sarcoma and whether the
changes of 31PMRS parameters is earlier than the changes of tumor volume. Methods: Murine
S180 sarcoma (s.c.) was studied by using surfacecoil 31PNMR. Results: Twentyfour hours after
cyclophosphamide treatment,PCr/Pi and NTP/Pi ratios of CTX treated groups increased
significantly relative to control (P< 005).PME/NTP ratio of CTX treated groups was lower than
those of control (P< 005). The tumor volume between treated groups and control group showed
no significant difference before 72h aflter treatment. Conclusions:31PMRS of mouse S180
sarcoma could not only provide quantitative information,but also show earlier response to
therapy than the change of tumor volume. |
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| Keywords: | 31PMRS |
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