| 核糖核酸酶抑制因子对小鼠S180的抑制作用机制研究 |
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| 引用本文： | 于秀萍,高颖.核糖核酸酶抑制因子对小鼠S180的抑制作用机制研究[J].实用肿瘤杂志,1999,14(1):23-25. |
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| 作者姓名： | 于秀萍 高颖 |
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| 作者单位： | 大连医科大学生化教研室 |
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| 摘 要： | 研究核糖核酸酸抑制因子对小鼠实体瘤生长的影响以及ＲＩ抑制肿瘤生长的机理。方法经硫酸铵盐析，ＤＥＡＥ－离子交换层析和Ｓｅｐｈａｒｏｓｅ－ＲＮａｓｅ亲和层析，从人胎盘中提取纯化核糖核酸酶抑制因子（ｒｉｂｏｎｕｃｌｅａｓｅｉｎｈｉｂｉｔｏｒ，ＲＩ），将其注射给荷瘤小鼠。
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| 关 键 词： | 肉瘤180 病理学 血管生成因子 小鼠 RI 抑瘤作用 |
The effect of ribonuclease inhibitor on the growth of mouse S 180 sarcoma |
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| Yu Xiuping,Gao Ying,Tian Yuxiang et al.The effect of ribonuclease inhibitor on the growth of mouse S 180 sarcoma[J].Journal of Practical Oncology,1999,14(1):23-25. |
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| Authors: | Yu Xiuping Gao Ying Tian Yuxiang |
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| Abstract: | Objective To investigate the effect of ribonuclease inhibitors on growth of solid tumor in mice.Methods Ribonuclease inhibitor(RI)was purified from human placenta by sepharose RNase chromatography and injected into mice transplanted with S 180 sarcoma to observe the tumor growth.Results RI inhibited the growth of S 180 sarcoma. The tissue slice showed that the number of capillary vessels was decreased and dead portion was increased. Conclusions RI inhibited S 180 sarcoma growth in mice and the suggested mechanism was that RI inhibited the growth of new blood vessel in the tumor |
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| Keywords: | sarcoma 180/pathology angiogenesis factor ribonuclease inhibitors mice |
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