海南地区宫颈癌病例的HPV感染状况

 目的　分析本地区宫颈癌患者的HPV感染情况。方法　收集 10 1例治疗前病例的颈管分泌物 ,用PCR荧光定量方法进行HPV6、11、16、18的检测。结果　HPV阳性者 4 4例 ,阳性率 4 3.6 % ,在 <4 0岁、4 0～ 5 0岁、>5 0岁 3个年龄段 ,HPV阳性率分别为 5 9.5 %、35 .9%、2 5 % (P <0 .0 5 )。近 2年与 2年前病例HPV感染率分别是 5 0 %、33.3%。宫颈鳞癌的HPV阳性率明显高于腺癌、腺鳞癌 (P <0 .0 1)。结论　HPV感染是宫颈癌的重要致病因素 ;鳞癌的发生与HPV感染的关系较腺癌更密切 ;在本地区极可能存在除上述 4型以外的已定或未定亚型的感染

The state of HPV infection of cervical carcinoma in Hainan area

Objective To study the state of HPV infection of cervical cancer.Methods 101 patients of cervical cancer were collected secretion of cervical canal before treatment. the samples were quantitative checked on HPV using PCR fluorescent ration.Results The positive rate of HPV was 43.6%. The positive rate of <40years;40-50 years;>50years was 59.5%;35.9%;25% separately.The infection rate in recent 2 rears was higher than 2 years ago (50%, 33.3% separately).The positive rate of squamocellular cancer was higher than adenocarcinoma obviously .Conclusion HPV infection is a major pathogeny of cervical carcinoma. The relationship of HPV infection in squamocarcinoma is more close than adenocarcinoma. It is likely that the known or unknown types are exist in this area beside of the HPV6,11,16,18.