急性白血病不同病期端粒酶活性及其预后意义初探

目的：观察急性白血病（AL）不同病期端粒酶活性及其与AL预后的关系。方法：用端粒重复扩增酶联免疫法进行端粒酶活性半定量测定。结果：（1）初发AL端粒酶活性与首次完全缓解（CR）期无显著差异而与CR期超3个月者差异显著；（2）CR3个月后持续高端粒酶活性提示缓解期短，预后不佳。结论：CR3个月后端粒酶活性可作为预后判定指标之一，而发病前端端酶活性与预后无关。

Telomerase activity and it's clinical significance in acute leukemia in different stages

Objective To observe the relationship between telomerase activity in acute leukemia in different stages and the prognosis of the disease.Method To semi quantitatively determine the telomerase activity by means of TRAP ELISA.Results (1)No significant difference of telomerase activity in acute leukemia(AL) is found between the disease at primary stage and at first complete remission(CR) stage.While the difference between the disease at primary stage and three months after first CR is of significance.(2)A sustained high activity of telomerase suggests a short remission period and an unfavorable prognosis at three months after CR.Conclusion Telomerase activity at three months after CR may serve as one of the parameters of the prognosis of the disease.There is no relationship between the premorbid telomerase activity and the prognosis.