^99mTc-MIBI与^99mTc-Octreotide生长抑素受体显像诊断乳腺癌的对比研究

目的:比较99mTcMIBI与99mTcOctreotide生长抑素受体显像对乳腺癌诊断的临床价值。材料和方法:对36例怀疑为乳腺癌的患者术前行99mTcMIBI显像,48小时后行99mTcOctreotide生长抑素受体显像,以术后病理检查结果作为金标准。结果:36例中,25例为乳腺癌,其中11例发生腋窝淋巴结转移;11例患者为乳腺良性病变。两种显像方法对乳腺癌诊断的灵敏度、特异性、准确性分别为92.0%、63.6%、83.3%和92.0%、27.3%、72.2%。结论:99mTcMIBI显像与99mTcOctreotide生长抑素受体显像对乳腺癌均有较好的诊断价值,但99mTcOctreotide生长抑素受体显像诊断特异性较低。由于本研究的病例数有限,有待于进一步的工作深入探讨。

Comparison of 99mTc-Methoxyisobutylisonitrile and 99mTc-Octreotide Scintimammography in the Diagnosis of Breast Cancer

Purpose: To compare the diagnostic value of 99mTc-Methoxyisobutylisonitrile(MIBI) and 99mTc-Octreotide scintimammography for breast cancer. Materials and Methods: 36 patients with breast neoplasm underwent scintimammography with 99mTc-MIBI first and 99mTc-Octreotide 48 hours later. The final diagnosis were confirmed by histopathology. Results :Out of the 36 patients, 25 had malignant tumors, 11 with lymph node involvement; and the other 11 had benign lesions. The sensitivity, specificity and accuracy of 99mTc-MIBI and 99mTc-Octreotide scintimammography were 92.0%, 63.6%, 83.3% and 92.0%, 27.3%, 72.2% respectively. Conclusion: Both 99mTc-MIBI imaging and 99mTc-Octreotide scintimammography are sensitive methods to diagnose breast cancer, while the specificity of 99mTc-Octreotide lower.