血液肿瘤并发真菌血症23例

 目的　对恶性血液肿瘤并发真菌血症的临床及微生物学特征进行分析，为临床诊治提供参考。方法　对23例恶性血液肿瘤并发真菌血症的临床资料、危险因素、真菌菌群分类以及治疗及预后进行回顾性分析。结果　真菌血症患者病情危重，大多有2种或2种以上的危险因素；菌种分布显示白假丝酵母菌占47 ％；近平滑假丝酵母菌占17 ％；光滑假丝酵母菌占12 ％。23例患者中，13例治愈（56.5％）、8例死亡（34.7 %）；2例放弃（8.6 %）。结论　对有高危因素的恶性血液肿瘤患者应重视真菌血症的发生，积极治疗原发病，加强病原学检测和药敏试验，及时早期诊断并合理选用抗真菌药物可改善预后。

Clinical analysis of 23 patients in hematologic neoplasms with fungemia

Objective To investigate the epidemiology of patients in malignant hematologic neoplasms with fungemia and provide evidence for clinical therapy. Methods 23 cases of patients of malignant hematologic neoplasms with fungemia concurrent clinical material, the dangerous factor, the fungus colony classification as well as the treatment and the prognosis were carried on the review analysis. Results Each patient with fungemia was seriously ill with two or more predisposing factors;Candida ablicans accounted for 47%;the rate of candida parapsilosi, candida tropicalis were 17%, 12%. In the 23 cases of patients,13 cases of patients cure (56.5%), 8 cases of patients died (34.7%);2 cases of patients give up (8.6%). Conclusion Fungemia in the patients of malignant hematologic neoplasms usually occurred with predisposing factors. Important measures to reduce mortality include curing the underlying diseases, emphasis on mornitoring fungal pathogen and susceptibility tests, early diagnosis and compliance medication principles.