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L''expérience française de l''utilisation d''un projecteur de source pour la curiethérapie prostatique exclusive par implants permanents d''iode radioactif : faisabilité et données de toxicité aiguë |
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| Authors: | P. Pommier M. Delannes O. LeFloch V. Bernier M.-H. Baron L. Thomas C. Malet J. Bonnet P. Louisot P. Aletti O. Goubard A. Chemin F. Chirat S. Lebivic X. Montbarbon J.-M. Bachaud L. Votron O. Lasbareilles O. Desmettre G. Bringeon F. Gassa D. Peiffert |
| Affiliation: | 1. Centre Léon-Bérard, 28, rue Laënnec, 69373 Lyon, France;2. Centre Claudius-Regaud, 31052 Toulouse, France;3. CHRU de Tours, 37044 Tours, France;4. Centre Alexis-Vautrin, 54511 Vandœuvre-lès-Nancy, France;5. Hôpital Minjoz, 25030 Besançon, France;6. Institut Bergonié, 33076 Bordeaux, France;7. Infirmerie protestante, 69300 Caluire, France;1. Department of Radiation Sciences, Umeå University, Umeå, Sweden;2. Medical Radiation Physics, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;1. Service d’urologie, faculté de médecine Pierre-et-Marie-Curie, université Paris 6, hôpital Pitié-Salpêtrière, AP–HP, 47–83, boulevard de l’Hôpital, 75651 Paris cedex 13, France;2. Service d’urologie, groupe hospitalier Diaconesses Croix Saint-Simon, 12–18, rue du Sergent-Bauchat, 75012 Paris, France;1. IFP Energies Nouvelles, Rond-point de l’échangeur de Solaize 69360 Solaize, France;2. Univ Lyon, INSA-LYON, MATEIS, UMR CNRS 5510, F69621 Villeurbanne, France |
| Abstract: | PURPOSE: To analyse a new technique for prostate brachytherapy with permanent Iodine implants characterized by the use of a seed projector after a 3D dosimetric peroperative treatment planning (FIRST technique). PATIENTS AND METHOD: 395 patients have been treated in France with this technique in six radiotherapy centres between November 2002 and December 2005 for a localized prostate cancer. RESULTS: Thirteen patients (3.3%) developped a urinary retention, and respectively 7.8 and 26.5% an acute RTOG grade 3 and 2 toxicity. The 6-weeks IPSS score was equal or lower to 15 in 73% with a 11 median IPSS value. A failure of the loading with the seed-projector, leading to a manual loading of the seeds, occurred in 9 patients (2.3%) in two centres, directly related to the loading procedure with the seed-projector in 5 cases. The median duration of the procedure was reduced by 30 minutes for the patients treated in 2005. CONCLUSIONS: This multicenter study establishes the feasibility of the routine use of a seed projector for permanent iodine 125 prostate implants with an initial tolerance similar to the best results published for other implants techniques. |
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