流行性出血热患者早期免疫应答的研究

应用反向被动血凝集抑制试验和血凝集抑制试验检测流行性出血热患者早期血清（７病日内）中病毒核蛋白、膜蛋白抗体。１０３例患者血清,仅核蛋白抗体出现者３３例,病情转径及无变化者３１例（９３．９４％）．而转重者仅２例（６．０６％）,且其血清抗体主要为ＩｇＧ型。仅膜蛋白抗体出现的患者９例,病情转重者８例（８８．８９％）,其抗体主要为ＩｇＭ．核蛋白、膜蛋白抗体均阳性的６１例患者,病情转归介于上述二者之间．提示：核蛋白抗体先出现的患者,病情多转轻,而膜蛋白抗体先出现的患者,病情普遍转重,似与病毒的＂一次性打击＂有关。在仅核蛋白抗体出现的患者中,有２例病情转重,但其抗体球蛋白类型为ＩｇＧ,故尚不能排除本病有＂二次感染＂的可能,这一现象在推行本病预防接种时值得重视,另对进一步探讨本病的发病机理及预测患者的病情转归亦具参考价值。

STUDY ON EARLY IMMUNE RESPONSE OF EHF PATIENTS

M P,NP antibodies in the early sera of 103 EHF patients (within 7 days)were detected by HI, RPHI. In 9 cases of only appearing M P antibody 8 became worse(88.89%),immunoglubolin of which was mainly IgM; in 33 cascs of only appearing NPanatibody 31 became better or unchange (93. 94%),2 became worse(6.06%),im munoglubolin of which was IgG; the patients cover of 61 cases of both M P, NPantibodies positive were somewhere between the above two,The results showed that themost patients first detectcd NP antibody became better but the patients first detected M Pantibody became generally worse,which possibly was relatcd to " single hit" of EHFviruses.2 patients of only appearing N P antibody (IgG) became worse,which is consideredto be "second infection" of EHF viruses that is important in vaccine inoculation. The resultalso proved that the detection of NP,MPantibodies in the early sera of EHF patients couldforecast patient cover and may be usefuI to probe into mechanism of the disease.