| 狗鼻粘膜血管α肾上腺素受体亚型分析 |
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| 引用本文： | 韩启德,李金玲,白燕. 狗鼻粘膜血管α肾上腺素受体亚型分析[J]. 北京大学学报(医学版), 1992, 0(1) |
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| 作者姓名： | 韩启德 李金玲 白燕 |
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| 作者单位： | 北京医科大学第三医院心血管研究室(韩启德)，兰州军区军医学校生理教研室(李金玲)，北京医科大学第三医院心血管研究室(白燕) |
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| 摘 要： | 采用离体标本收缩功能实验方法显示,狗鼻粘膜血管上的α肾上腺素受体(α受体)主要为α_1受体,包含α_(1A)与α_(1B)两种亚型。以去甲肾上腺素为标准,比较了10种临床上作为抗鼻粘膜充血药物的α受体激动剂对鼻粘膜血管α_1受体的内在活性与相对效率,并比较了去甲肾上腺素与苯肾上腺素对α_(1A)与α_(1B)受体的强度、亲和性与受体储备。
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| 关 键 词： | α肾上腺素受体 受体亚型 鼻粘膜 抗充血剂 |
ANALYSIS OF ALPHA-ADRENOCEPTOR SUBTYPES IN BLOOD VESSELS OF CANINE NASAL MUCOSA |
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| Han Qide,et al Cardiovascular Research Laboratory,The Third Hospital. ANALYSIS OF ALPHA-ADRENOCEPTOR SUBTYPES IN BLOOD VESSELS OF CANINE NASAL MUCOSA[J]. Journal of Peking University. Health sciences, 1992, 0(1) |
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| Authors: | Han Qide et al Cardiovascular Research Laboratory The Third Hospital |
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| Abstract: | The subtypes of alpha-adrenoceptos in blood vessels of canine nasal mucosa were determined bycontractile functional experiments in isolated preparations. The results showed there exist predominantlyalpha 1-adrenoceptors, which could be divided further into two subtypes--alpha 1A-and alpha 1B-adrenoceptor. The intrinsic activities and relative efficacies of 10 alpha-adrenoceptor agonists which areused clinically as nasal mucosa congestants were determined and compared with norepinephrine (NE).The potencies, affinities and receptor reserves for NE and phenylephrine were also compared betweenalpha 1A-and alpha 1B-adrenoceptors. |
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| Keywords: | Alpha-adrenoceptor Receptor subtypes Nasal mucosa Congestant |
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