Plk1和p27在甲状腺乳头状癌中的表达及预后意义

目的:探讨Plk1和p27在甲状腺乳头状癌中的表达及与甲状腺乳头状癌预后的关系。方法:采用免疫组织化学技术检测Plk1和p27在甲状腺乳头状癌中的表达情况。结果:甲状腺乳头状癌中Plk1的阳性表达率明显高于正常甲状腺组织（P<0.05）。Plk1在微灶癌（直径≤1cm）中的阳性表达率明显高于在癌灶直径>1cm的甲状腺乳头状癌(P<0.05)。甲状腺乳头状癌中p27阳性表达率（44.12%）明显低于正常甲状腺组织（80.00%，P<0.05）。Plk1和 p27表达与包膜浸润、淋巴结转移情况相关。结论:Plk1在早期甲状腺乳头状癌的发生、发展中起重要作用，联合检测Plk1和p27 有助于甲状腺乳头状癌的诊断及预后评估。

Plk1 and p27 expression in thyroid papillary carcinoma and prognostic value

To identify the expression of Plk1 and p27 and to discuss its relationship with prognosis in thyroid papillary carcinoma. Methods：Plk1 protein expression level in thyroid papillary carcinomas was detected by immunohistochemistry method. Results：The positive expression rate of Plk1 in thyroid papillary carcinoma was signifi-cantly higher than that in normal thyroid（P ﹤ 0. 05）. The expression in thyroid papillary microcarcinoma（≤1cm） tissues was significantly higher than that in larger thyroid papillary carcinoma（ ﹥ 1cm）tissues（P ﹤ 0. 05）. The posi-tive expression rate of p27 in the thyroid papillary carcinoma 44. 12% was significantly lower than that in normal thy-roid 80. 00%（P ﹤ 0. 05）. The positive expression of Plkl and p27 was correlated with lymph node metastasis,envelop invasion（P ﹤ 0. 05）. Conclusion：Plk1 plays a constitutive role in the carcinogenesis and progression in thyroid pa-pillary carcinoma especially in the early phase,markedly correlated with the expression of Plk1 and p27 may be a powerful and aid in evaluating prognosis and infiltrative capability of thyroid papillary carcinoma.