At Least Two Loci of the Major Histocompatibility Complex Can Determine Mixed Lymphocyte Stimulation in the Rat |
| |
| Authors: | Eberhard Gü nther,Otakar &# tark |
| |
| Affiliation: | Max-Planck-Institut für Immunbiologie, Freiburg, W. Germany;Charles University, Prague, Czechoslovakia |
| |
| Abstract: | Analysis of a recombinant haplotype of the major histocompatibility complex showed that two genetically separable loci (or groups of loci), LD--1 and LD--2, determine mixed lymphocyte stimulation in the rat. LD--1 maps into the H--1B region which contains the Ir genes and is associated with strong, mixed lymphocyte stimulation. LD--2 maps into the H--1A region and determines weak stimulation. LD--1 and LD--2 determinants can be detected by primed lymphocyte typing. |
| |
| Keywords: | |
|
|
