| 慢传输型便秘乙状结肠壁内一氧化氮合酶分布的免疫组化研究 |
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| 引用本文： | 童卫东,张胜本,张连阳,杜文华,牟江洪,高峰. 慢传输型便秘乙状结肠壁内一氧化氮合酶分布的免疫组化研究[J]. 结直肠肛门外科, 1998, 0(2) |
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| 作者姓名： | 童卫东 张胜本 张连阳 杜文华 牟江洪 高峰 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所!重庆400042(童卫东，张胜本，张连阳，杜文华，牟江洪)，第三军医大学大坪医院野战 (高峰) |
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| 摘 要： | 对15例慢传输型便秘(STC)患者乙状结肠壁内一氧化氮合酶(NOS)的分布进行免疫组织化学研究和半定量分析,结果表明肌间神经丛NOS阳性细胞明显增多(P<0.05),粘膜下丛无明显变化(P>0.05).提示一氧化氮的过量产生抑制了肠平滑肌的收缩,可能是STC发病的原因之一.
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| 关 键 词： | 便秘 一氧化氮 肠神经系统 |
AN IMMUNOHISTOCHEMISTRY STUDY OF NITRIC OXIDESYNTHASE DISTRIBUTION IN SIGMOID COLON OF SLOW TRANSIT CONSTIPATION |
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| Daping Hospital and Research institute of Field Surgery,the Third Military Medical University,Chongqing ,Tong Weidong,Zhang Shengben,Zhang Lianyang,et al. AN IMMUNOHISTOCHEMISTRY STUDY OF NITRIC OXIDESYNTHASE DISTRIBUTION IN SIGMOID COLON OF SLOW TRANSIT CONSTIPATION[J]. Journal of Colorectal & Anal Surgery, 1998, 0(2) |
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| Authors: | Daping Hospital Research institute of Field Surgery the Third Military Medical University Chongqing Tong Weidong Zhang Shengben Zhang Lianyang et al |
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| Affiliation: | Daping Hospital and Research institute of Field Surgery,the Third Military Medical University,Chongqing 400042,Tong Weidong,Zhang Shengben,Zhang Lianyang,et al |
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| Abstract: | By using semiquantitative immunohistochemistry, the distribution of nitric oxide syn-thase (NOS) in the sigmoid colons of 15 patients with slow transit costipation (STC) were investigated. The density of NOS positive neurons was higher in the myenteric plexus (P <0. 05), while at the submucous plexus there was no difference between the STC group and thecontrol group (P >0. 05). This suggest that an excessive production of NOS may cause persis-tent inhibition of contractions which could be one of the reasons of slow transit colon. |
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| Keywords: | constipation nitricoxide enteric nervous system |
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