影响胃肠道肿瘤患者生命质量相关因素的初步评价

目的：评价消化道肿瘤中胃癌、大肠癌患者的生命质量，探讨影响其生命质量的相关因素。方法：采用癌症患者生命质量测定量表核心量表（EORTC QLQ C30，简称QLQ C30）调查35例胃癌患者和40例大肠癌患者，对大肠癌患者QLQ C30得分与参考值进行比较，并对不同年龄、性别、文化程度、病种、病期及经过治疗与否患者的QLQ C30得分进行比较。结果：（1）大肠癌患者的各项生命质量指标均低于国外参考值（P〈0．05）。（2）大肠癌组、高文化程度组功能子量表得分较高（P〈0．05）；经过综合治疗的患者、较早期患者的功能子量表得分较高而症状子量表得分较低；在不同分组方式下均有多个子量表或单项量表的得分存在组间差异（P〈0．05）。结论：高文化程度患者、较早期患者、经过综合治疗后的患者的生命质量较好。而年龄、性别对生命质量的影响不大。胃癌患者相对于大肠癌患者生命质量较差。该研究结果对建立中国胃癌、大肠癌患者生命质量的评判标准及临床诊疗工作有一定的指导意义。

The rudiment assessment for the correlation factors of the quality of life in gastrointestinal cancer patients

Objective: To evaluate the quality of life (QoL) of gastric cancer and colorectal cancer patients and to investigate the differences in QoL with respect to social and medical characteristics. Methods: Structured questionnaires EORTC QLQ C30(QLQ C30)were used in 35 cases with gastric cancer and 40 cases with colorectal cancer. This 40 cases of colorectal cancer were also compared with reference value. The T-test and one-way analysis of variance (ANOVA) were used to compare the differences in QoL at a 5% level of significance. Results: (1) The QoL of colorectal cancer patients were worse than reference value (P < 0. 05). (2) The colorectal cancer patients and the patients with high education had high functional scales score, the patients having experienced the combined therapy or at the early stages had higher functional scales score and lower symptom scales score (P<0. 05). In different grouping way, it always have significant difference among several groups in some functional scales, symptom scales or single items (P