| 慢性鼻窦炎相关内在型分类及血液标志物的研究进展 |
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| 引用本文： | 毛弈友,陈杰,廖敏,李双,刘江怡,陈卓,杨玉成.慢性鼻窦炎相关内在型分类及血液标志物的研究进展[J].中国耳鼻咽喉颅底外科杂志,2020,26(3):338-342. |
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| 作者姓名： | 毛弈友 陈杰 廖敏 李双 刘江怡 陈卓 杨玉成 |
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| 作者单位： | 重庆医科大学附属第一医院 耳鼻咽喉科 重庆医科大学第一临床学院，重庆400016 |
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| 基金项目： | 国家自然科学基金项目(81970864); 重庆市中青年医学高端人才工作室项目［渝卫人（2018）2号］; 重庆医科大学附属第一医院学术带头人储备人才基金项目［2019］;重庆市卫计委重点项目(2015HBRC004)；重庆市科委重点项目(cstc2015jcyjBX0047)；重庆市卫计委中医药项目(ZY201702070)。 |
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| 摘 要： | 目的随着慢性鼻窦炎(CRS)内在型及血液标志物的相关研究不断取得进展，CRS的治疗已经开始向精准医学时代迈进。本文总结了CRS的内在型分类及CRS内在型与血液标志物的关系，并重点介绍了以II型炎症反应血液标志物为首的CRS血液标志物目前在CRS中的研究进展。我们期望找到更符合临床需要的血液标志物，为建立相应的CRS内在型分型提供依据，以便更好地指导CRS的个性化治疗及预后判断。
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| 关 键 词： | 鼻窦炎|II型炎症|细胞因子|生物标志物|免疫特定靶点 |
Research progress on blood markers and endotypes classification of chronic rhinosinusitis |
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| MAO Yiyou,CHEN Jie,LIAO Min,LI Shuang,LIU Jiangyi,CHEN Zhuo,YANG Yucheng.Research progress on blood markers and endotypes classification of chronic rhinosinusitis[J].Chinese Journal of Otorhinolaryngology-skull Base Surgery,2020,26(3):338-342. |
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| Authors: | MAO Yiyou CHEN Jie LIAO Min LI Shuang LIU Jiangyi CHEN Zhuo YANG Yucheng |
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| Institution: | Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University,the First Clinical College of Chongqing Medical University,Chongqing 400016,China |
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| Abstract: | ObjectiveWith the development of the endotypes classification and blood markers of chronic rhinosinusitis(CRS), the treatment of CRS has ushered in the era of precision medicine. This paper summarizes the endotypes classification of CRS, and the relationship between CRS endotypes types and blood markers. And the article focuses on the progress of the current research for CRS blood markers led by type 2 inflammation blood markers in CRS. We hope to find blood markers that are more suitable for clinical detection, which will lay the foundation for establishing the corresponding endotypes classification of CRS. It will guide the better personalized treatment of CRS and evaluate the prognosis of CRS. |
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| Keywords: | Sinusitis| Type 2 inflammation|Cytokine| Biomarkers|Immune specific targeting |
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