| Bcl-2和p53蛋白在牙龈增生中的表达研究 |
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| 引用本文： | 张睿,刘娇艳,李德纯,张明珠,彭艺,税艳青.Bcl-2和p53蛋白在牙龈增生中的表达研究[J].口腔医学研究,2021,37(4):300-303. |
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| 作者姓名： | 张睿 刘娇艳 李德纯 张明珠 彭艺 税艳青 |
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| 作者单位： | 昆明医科大学附属口腔医院牙周病科 云南 昆明 650100;昆明医科大学口腔医学院 云南 昆明 650500 |
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| 基金项目： | 昆明医科大学大学生创新性实验计划省级项目(329) |
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| 摘 要： | 目的:研究Bcl-2(B-cell leukemia-2)蛋白和p53蛋白在牙龈增生中的表达,探讨其与增生牙龈中抗凋亡作用机制的相关性.方法:选择符合临床诊断的11例炎症性牙龈增生患者作为实验组,正常牙龈组织11例作为对照组;通过免疫组织化学法探究增生牙龈组织和正常牙龈组织中Bcl-2蛋白和p53蛋白的表达情况.结果:...
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| 关 键 词： | 牙龈增生 抗凋亡作用 Bcl-2蛋白 p53蛋白 |
Expressions of Bcl-2 and p53 Proteins in Gingival Hyperplasia |
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| ZHANG Rui,LIU Jiaoyan,LI Dechun,ZHANG Mingzhu,PENG Yi,SHUI Yanqing.Expressions of Bcl-2 and p53 Proteins in Gingival Hyperplasia[J].Journal of Oral Science Research,2021,37(4):300-303. |
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| Authors: | ZHANG Rui LIU Jiaoyan LI Dechun ZHANG Mingzhu PENG Yi SHUI Yanqing |
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| Institution: | (Department of Periodontics, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming 650100, China;School of Stomatology, Kunming Medical University, Kunming 650500, China) |
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| Abstract: | Objective:To study the expressions of Bcl-2 protein and p53 protein in gingival hyperplasia,and to explore their correlation with the anti-apoptotic mechanism of gingival hyperplasia.Methods:11 cases of gingival hyperplasia caused by inflammation in accordance with the clinical diagnosis were selected as the experimental group and 11 cases of normal gingival tissue as the control group.The expressions of Bcl-2 and p53 proteins in the hyperplastic and normal gingival tissue were investigated by immunohistochemistry.Results:The positive expressions of Bcl-2 protein and p53 protein in hyperplastic gingival tissue were both significantly higher than those in normal gingival tissue(P<0.05).Conclusion:Bcl-2 protein and p53 protein play an important role in gingival hyperplasia,and the anti-apoptosis may involve in the pathogenesis of gingival hyperplasia. |
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| Keywords: | gingival hyperplasia anti-apoptosis Bcl-2 protein p53 protein |
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