用纵向队列法分析昆明地区体检人群同型半胱氨酸对血压、血糖及血脂的影响

目的 通过纵向队列研究分析同型半胱氨酸(homocysteine,Hcy)对血压、血糖及血脂变化的影响,为相关慢性疾病的防治提供依据.方法 选取在2017年基线调查之后2 a期间每年体检调查中具有完整资料的体检人员987人作为研究对象,构建纵向研究队列,收集其基本信息、Hcy、空腹血糖、空腹血脂以及血压测量结果.根据末...

A Longitudinal Cohort Study on the Effects of Homocysteine on Blood Pressure,Blood Glucose and Blood Lipid in Physical Examination Population in Kunming

  Objective  To analyze the effects of homocysteine （Hcy） on blood pressure, blood glucose and blood lipid in a longitudinal cohort study, so as to provide basis knowledge for the prevention and treatment of related chronic diseases.  Methods  987 physical examination personnel with complete data in the annual physical examination survey during the two-year period after the 2017 baseline survey were selected as study subjects to construct a longitudinal study cohort. We collected demographic characteristics, homocysteine, blood pressure, blood glucose and blood lipid, and based on the homocysteine change, divided them into three groups: the non-change group （normal-normal; abnormal-abnormal）, normal-abnormal group, abnormal-normal group. Generalized linear regression model was used to analyze the relationship between homocysteine change and the changes in blood pressure, blood glucose and blood lipid.  Results  The average age of participants in baseline survey was （43.63±11.4） years with a range of 23 to 85 years. During the three-year period, there were 50.25%（496）, 14.39%（142）, 35.36%（349） people with non-change group （normal-normal;Abnormal-abnormal）, normal-abnormal group, abnormal-normal group, The Hcy change was taken as the dependent variable for analysis. Univariate analysis showed that, compared with the non-changed group, systolic blood pressure in the abnormally normal group was significantly reduced （P < 0.05）, and there were no statistical differences in other indicators. Based on generalized linear model, after adjustment for age, gender, baseline BMI, drinking, smoking, results show that when compared with the non-change group, the systolic blood pressure, total cholesterol, blood sugar of anomaly-normal group were significantly decrease （P < 0.05）, and the drop-out value were 2.132, 0.203, 0.182 respectively. There was no significant difference in the change of diastolic blood pressure, triglyceride, High-density lipoprotein and low-density lipoprotein.  Conclusion  The change of Hcy is related to the change of systolic blood pressure, total cholesterol and blood glucose, and the decrease of Hcy is conductive to the improvement of blood glucose, blood pressure and lipid levels.