| 多发性硬化/实验性自身免疫性脑脊髓炎中树突状细胞亚群的研究进展 |
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| 引用本文： | 彭永,甘露,杨珊珊,杨欢.多发性硬化/实验性自身免疫性脑脊髓炎中树突状细胞亚群的研究进展[J].国际神经病学神经外科学杂志,2020,47(4):435-438. |
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| 作者姓名： | 彭永 甘露 杨珊珊 杨欢 |
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| 作者单位： | 1. 湖南中医药高等专科学校附属第一医院神经内科, 湖南 株洲 412000;2. 中南大学湘雅医院神经内科, 湖南 长沙 410008 |
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| 基金项目： | 湖南省中医药管理局重点课题（201915）；湖南省自然科学基金（2018JJ6043）；湖南省卫计委课题（B20180815）；株洲市科技局课题（20160104） |
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| 摘 要： | 树突状细胞（DC）与T细胞同为多发性硬化（MS）的主要责任细胞。DC与先天性和获得性免疫系统密切相关，并可促进或抑制髓鞘抗原特异性免疫反应。DC亚群是自身免疫反应结局的重要决定因素，但其组织特异性也可能与DC亚群的功能有关。因此，该文综述了近10年来的最新文献，深入了解DC亚群的表型、功能及其在多发性硬化症及其动物模型中的作用，有助于基于DC亚群设计免疫干预方案来治疗MS。
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| 关 键 词： | 多发性硬化|实验性自身免疫性脑脊髓炎|树突状细胞亚群|T细胞|髓鞘抗原 |
| 收稿时间： | 2020/4/15 0:00:00 |
| 修稿时间： | 2020/6/27 0:00:00 |
Research advances in dendritic cell subsets in multiple sclerosis/experimental autoimmune encephalomyelitis |
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| PENG Yong,GAN Lu,YANG Shan-Shan,YANG Huan.Research advances in dendritic cell subsets in multiple sclerosis/experimental autoimmune encephalomyelitis[J].Journal of International Neurology and Neurosurgery,2020,47(4):435-438. |
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| Authors: | PENG Yong GAN Lu YANG Shan-Shan YANG Huan |
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| Institution: | 1. Department of Neurology, Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou 412000, Hunan, China;2. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China |
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| Abstract: | Dendritic cells (DCs) and T cells are mainly responsible for multiple sclerosis (MS). DCs are closely associated with innate and acquired immune systems and may promote or inhibit the specific immune response to myelin antigen. DC subsets are an important factor for the outcome of autoimmune response, and its tissue specificity may also be associated with the function of DC subsets. Therefore, this article reviews the latest research advances in the past 10 years, so as to understand the phenotype and function of DC subsets and their role in MS and related animal models and help to design immune intervention regimens for the treatment of MS based on DC subsets. |
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| Keywords: | multiple sclerosis|experimental autoimmune encephalomyelitis|dendritic cell subset|T cell|myelin antigen |
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