| 云南籍几个正常人群间GSTM1基因多态性的比较研究 |
| |
| 引用本文： | 梁子卿,宋忠魁,夏晓玲,黄云超,镡颖,汪旭.云南籍几个正常人群间GSTM1基因多态性的比较研究[J].癌变．畸变．突变,2002,14(1):22-24. |
| |
| 作者姓名： | 梁子卿 宋忠魁 夏晓玲 黄云超 镡颖 汪旭 |
| |
| 作者单位： | 1. 云南师范大学生命科学学院遗传教研室,云南,昆明,650092;2. 昆明医学院第二附属医院胸外科,云南,昆明,650031 |
| |
| 基金项目： | 云南省自然科学基金;2000C0046M; |
| |
| 摘 要： | 目的: 针对云南曲靖地区宣威县、富源县及非曲靖地区3组正常人群进行GSTM1基因型多态性的比较研究.方法:采用聚合酶链反应(Polymerase chain reaction,PCR)技术对相关人群进行基因型鉴定.结果:GSTM1纯合缺失基因型(0/0)的频率在宣威人群为63.6%(n＝33),富源人群为64.5%(n＝31),非曲靖人群为68.5%(n＝35).结论:GSTM1基因型多态性在3个正常人群中的分布情况均一.该研究为了解特定地区肺癌与外源物代谢解毒基因之间的可能联系提供了一些基础数据.
|
| 关 键 词： | 谷胱甘肽硫转移酶M1基因 遗传多态性 正常人群 云南人群 |
| 文章编号： | 1004-616(2002)01-0022-03 |
| 修稿时间： | 2001年5月8日 |
STUDY OF GENETIC POLYMORPHISM OF GLUTATHIONE S-TRANSFERASE M1 AMONG THREE SUBPOPULATIONS IN YUNNAN PROVINCE |
| |
| LIANG Zi-qing,SONG Zhong-kui,XIA Xiao-ling,HUANG Yun-chao,CHAN Ying. WANG Xu.STUDY OF GENETIC POLYMORPHISM OF GLUTATHIONE S-TRANSFERASE M1 AMONG THREE SUBPOPULATIONS IN YUNNAN PROVINCE[J].Carcinogenesis,Teratogenesis and Mutagenesis,2002,14(1):22-24. |
| |
| Authors: | LIANG Zi-qing SONG Zhong-kui XIA Xiao-ling HUANG Yun-chao CHAN Ying WANG Xu |
| |
| Institution: | LIANG Zi-qing+1,SONG Zhong-kui+1,XIA Xiao-ling+2,HUANG Yun-chao+2,CHAN Ying. WANG Xu+1 |
| |
| Abstract: | Purpose: To compare the genetic polymorphism of glutathione S-transferase M1 (GSTM1) locus between the populations in Xuanwei and Fuyuan counties in Qujing city and between Qujing and non-Qujing residents in Yunnan province. Methods: Polymerase chain reaction (PCR) was employed to justify the genotype of the aim population. Results: No significant difference was found in the GSTM1 genotype frequencies among those three groups (P>0.05), i.e., the frequencies of GSTM1 null genotype (0/0) were 63.6% in Xuanwei residents, 64.5% in Fuyuan group and 68.5% in non-Qujing group, respectively. Conclusion: Among the normal populations studied, the genetic polymorphism distribution of GSTM1 genes was proved to be homogenous. The result is helpful for further research on the association on lung cancer and xenobiotics detoxification genes. |
| |
| Keywords: | GSTM1 gene genotype polymorphism normal population "Yunnan" population |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
