| VEGF/KDR在前列腺癌中的表达及其与肿瘤Gleason评分之间关系的研究 |
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| 引用本文： | 程汉波,冯亮. VEGF/KDR在前列腺癌中的表达及其与肿瘤Gleason评分之间关系的研究[J]. 江西医学院学报, 2009, 49(5) |
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| 作者姓名： | 程汉波 冯亮 |
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| 作者单位： | 南昌大学第一附属医院泌尿外科 |
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| 摘 要： | 目的探讨血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)和KDR在前列腺癌(pros-tate cancer,PCa)中的表达及其与肿瘤Gleason评分之间的关系。方法20例前列腺癌组织[按Gleason评分,将≥7分者列为高Gleason评分组(n=12);<7分者列为低Gleason评分组(n=8)]、良性前列腺增生(benign prosta-tic hyperplasia,BHP)15例,正常前列腺组织(normal prostate,NP)中VEGF、KDR的表达水平。结果PCa中VEGF、KDR阳性表达率高于BPH及NP(P均<0.05),高Gleason评分组中VEGF、KDR阳性表达率(83.3%,91.7%)高于低Gleason评分组(37.5%、62.5%,P<0.05)。结论VEGF、KDR在前列腺癌中均为高表达,且与肿瘤的Gleason评分密切有关。
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| 关 键 词： | 前列腺癌 Gleason评分 血管内皮生成因子 KDR |
Expression of VEGF and KDR in Human Prostate Cancer and Their Relationship with Gleason Score |
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| CHENG Han-bo; FENG Liang. Expression of VEGF and KDR in Human Prostate Cancer and Their Relationship with Gleason Score[J]. Acta Academiae Medicinae Jiangxi, 2009, 49(5) |
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| Authors: | CHENG Han-bo FENG Liang |
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| Affiliation: | CHENG Han-bo; FENG Liang(Department of Urology; The First Affiliated Hospital of Nanchang University; Nanchang 330006; China); |
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| Abstract: | Objective To investigate the expression of vascular endothelial growth factor(VEGF) and kinase domain containing receptor(KDR) in human prostate cancer(PCa) and their relationship with Gleason Score.Methods The expression of VEGF and KDR were dectected by immunohistochemistry method in 20 Pca,15 benign prostatic hyperplasia(BPH) and 10 normal prostate(NP).The PCa was divided into high Gleason score group(Gleason score≥7,n=12) and low Gleason score group(Gleason score<7,n=8).Results The positive rate of V... |
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| Keywords: | KDR |
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