小儿原发性肾病综合征并发感染133例临床分析

目的: 探讨小儿肾病综合征院内外感染的发生率及相关因素。方法: 回顾分析1997~2003年在我院儿科住院并随访的133例原发性肾病综合征患儿的临床资料。结果: 133例中合并医院感染20例(15.04%)合并院外感染84例(63.16%),其中呼吸道感染占多数。住院时间超过3周患儿医院感染的发生率达40%(P<0.05),但院外感染率与年长儿相似(P>0.05)。医院感染与免疫球蛋白IgG下降有关(P<0.01),而乡村患儿并发院外感染较多(P<0.01)。结论: 肾病综合征患儿易合并院内外感染,呼吸道感染最常见,医院感染与住院时间的长短及血浆免疫球蛋白水平成正相关,而院外感染则与居住环境有关。缩短住院时间、提高免疫球蛋白水平及改善居住环境可减少感染并发症,减少复发机会。

Primary nephrotic syndrome complicated with infection:Report of 133 cases

Objective:To explore the incidence of infection of primary nephrotic syndrome in childhood and the related factors.Methods:The clinical data of 133 cases hospitalized for primary nephrotic syndrome in our department(from 1997 to 2003) were analyzed.Results:Of the 133 cases of primary nephrotic syndrome,20 were complicated with nosocomial infection and 84 with community infection.Most of the infections occurred in the respiratory tract.The incidence of complication was about 40% when the length of hospital stay was over 3 weeks.Children under 3 years of age were more easily affected by nosocomial infection(P>0.05).Nosocomial infection was related to the decrease of the gammaglobulin level(P<0.01).Country children were more likely to be affected by community infection(P<0.01).Conclusions:Primary nephrotic syndrome tends to be complicated with infections,especially the respiratory infection.High incidence of infection,long length of hospital stay and low level of gammaglobulin are the risk factors.