Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy |
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Authors: | Morton C A Whitehurst C Moore J V MacKie R M |
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Affiliation: | University Department of Dermatology, Western Infirmary, Glasgow G11 6NT, UK. camorton@fdri2.fdri.scot.nhs.uk |
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Abstract: | BACKGROUND: A variety of protocols exist for the treatment of Bowen's disease by photodynamic therapy (PDT) using topical 5-aminolaevulinic acid (5-ALA). OBJECTIVE: To determine the optimal wavelength (red or green light) for this treatment. METHODS: A randomized comparison study of ALA-PDT using red (630 +/- 15 nm) or green (540 +/- 15 nm) light in the treatment of Bowen's disease. RESULTS: The initial clearance rate for lesions treated by red light was 94% (30 of 32) in comparison with 72% (21 of 29) for those lesions receiving green light (P = 0.002). Over the following 12 months, there were two recurrences in the red light group and seven in the green light group reducing the clearance rates to 88% and 48%, respectively. The frequency and severity of pain experienced were similar between the two treatment groups. No hyperthermia, nor significant difference in lesional temperatures, was observed between the wavelengths studied. CONCLUSION: Green light is less effective than red light, at a theoretically equivalent dose, in the treatment of Bowen's disease by topical ALA-PDT. |
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Keywords: | 5-aminolaevulinic acid Bowen's disease non-laser light source photodynamic therapy randomized controlled trial |
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