Formation of 5α-androstane-3β,17β-diol in the rat hypophysis |
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| Authors: | V. G. Degtyar' T. V. Babkina N. E. Kushlinskii |
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| Affiliation: | (1) N. N. Blokhin Oncology Research Center, Russian Academy of Sciences, Moscow |
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| Abstract: | Quantitative determination of 5α-androstane-3β,17β-diol (3β-D) during its synthesis from dihydrotestosterone in the hypophysis of intact and castrated ratsin vitro can be performed only in homogenate. Synthesis of 3β-D is enhanced after castration in rats of both sexes. Rapid conversion of 3β-D into other metabolites in integral hypophysisin vitro is supposed to underlie nonadequate determination of 3β-hydroxysteroidoxide reductase in this gland. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 2, pp. 149–152, April, 1997 |
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| Keywords: | rats hypophysis androgens metabolism |
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