| TL1A及其受体与炎症性肠病的研究进展 |
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| 引用本文： | 严冬梅. TL1A及其受体与炎症性肠病的研究进展[J]. 胃肠病学, 2010, 15(11): 684-686. DOI: 10.3969/j.issn.1008-7125.2010.11.012 |
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| 作者姓名： | 严冬梅 |
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| 作者单位： | 四川大学华西医院消化内科,610041 |
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| 摘 要： | 炎症性肠病(IBD)是病因不明的慢性非特异性肠道炎症性疾病,包括溃疡性结肠炎(UC)和克罗恩病(CD)。肿瘤坏死因子配体相关分子1A(TL1A)属肿瘤坏死因子(TNF)超家族成员,其受体包括死亡受体3(DR3)和诱骗受体3(DcR3)。近年研究发现,IBD肠黏膜TL1A及其受体表达异常可能与本病的发生相关。本文就TL1A及其受体与IBD相关性的研究进展作一综述。
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| 关 键 词： | 肿瘤坏死因子配体相关分子1A 炎症性肠病 免疫耐受 T淋巴细胞 |
Advances in Studies on TL1A and its Receptors in Inflammatory Bowel Disease |
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| YAN Dongmei. Advances in Studies on TL1A and its Receptors in Inflammatory Bowel Disease[J]. Chinese Journal of Gastroenterology, 2010, 15(11): 684-686. DOI: 10.3969/j.issn.1008-7125.2010.11.012 |
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| Authors: | YAN Dongmei |
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| Affiliation: | YAN Dongmei, HU Renwei. Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu (610041) |
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| Abstract: | Inflammatory bowel disease （IBD）, which includes ulcerative colitis （UC） and Crohn＇s disease （CD）, is chronic nonspecific inflammatory disorders of digestive tract with unknown etiology. Tumor necrosis factor （TNF）-like ligand 1 aberrance （TL1A） belongs to TNF superfamily, and its receptors include death receptor 3 （DR3） and decoy receptor 3 （DcR3）. Recent studies have found that abnormal expressions of TL1A and its receptors in intestinal mucosa of IBD might be correlated with the development of IBD. This article reviewed the advances in studies on correlation of TL1A and its receptors with IBD. |
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| Keywords: | Tumor Necrosis Factor-Like Ligand I Aberrance Inflammatory Bowel Disease Immune Tolerance T-Lymphocytes |
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