Transcranial magnetic stimulation over dorsolateral prefrontal cortex in Parkinson's disease. |
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| Authors: | Miguel Fernández del Olmo Olalla Bello Javier Cudeiro |
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| Institution: | 1. Service de neurochirurgie, hôpital Nord, 42055 Saint-Étienne cedex 2, France;2. Inserm U1028, Central Integration of Pain Unit, Lyon Neuroscience Research Center, 69000 Lyon, France;3. Intégration centrale de la douleur, université Jean-Monnet, 42023 Saint-Étienne, France;4. Service de radiologie centrale, hôpital Nord, 42055 Saint-Etienne cedex 2, France;5. Service de neurologie, hôpital Nord, 42055 Saint-Etienne cedex 2, France;1. Université de Lille, U1171 troubles cognitifs, dégénératifs et vasculaires, Lille, France;2. Service de Neurologie et Pathologie du mouvement, Hôpital Roger Salengro, CHU de Lille, Lille, France;3. Service de Neurophysiologie Clinique, Hôpital Roger Salengro, CHU de Lille, Lille, France;4. Université du Littoral Côte d’Opale, Calais, France;1. State University of Londrina, Robert Koch Av., 60, Londrina, Paraná, Brazil;2. State University of ABC, Dos Estados Av., 5001, Santo André, São Paulo, Brazil;1. School of Physical Therapy, Texas Woman’s University, 5500 Southwestern Medical Ave., Dallas, TX 75235, United States;2. Department of Communication Science and Disorders, Texas Woman’s University, 5500 Southwestern Medical Ave., Dallas, TX 75235,United States;3. School of Physical Therapy, Texas Woman’s University, 5500 Southwestern Medical Ave., Dallas, TX 75235, United States;1. Department of Neurology and Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Duesseldorf, Germany;2. Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy;3. Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom;4. Max-Planck Institute of Psychiatry, Munich, Germany;5. Berenson-Allen Center for Noninvasive Brain Stimulation and Division for Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States |
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| Abstract: | OBJECTIVE: Several studies have shown that repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) is effective in the treatment of depression in patients with Parkinson disease (PD). However, since research into the effect of this type of rTMS regime on motor function is limited, we studied the effect of rTMS over the DLPFC on the motor functions in PD patients. METHODS: Thirteen patients were randomly assigned into 2 groups, one receiving real-rTMS (90% of resting motor threshold, 10 Hz, 450 pulses-day for 10 consecutive days) over the DLPFC contralateral to the more affected side, and the other group receiving sham-rTMS. Assessment included a clinical motor evaluation using part III of the Unified Parkinson's Disease Rating Scale (UPDRS), and several motor tasks. The UPDRS was applied before and after 10 days of rTMS. Finger tapping, reach movement, grip movement and gait were measured in each session before and after the rTMS over the 10 day period. RESULTS: Statistical analysis (ANOVA for repeated measures; group *day *side *rTMS) only showed a significant effect for finger tapping, reach movement and gait for the factor day. No significant change was reported for the UPDRS in any group. CONCLUSIONS: Application of rTMS over the DLPFC as a 10 day course had no significant effect on motor functions and clinical motor status, and the improvement in performance of motor tasks can be attributed to the effects of practice. SIGNIFICANCE: rTMS over the DLPFC did not lead to any motor improvement in PD patients. |
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