高温碘油热栓塞治疗原发性肝癌患者

目的 探讨高温碘油血管栓塞及热杀伤作用对原发性肝癌的疗效。方法 将131例原发性癌患者随机分为两组：热碘油栓塞组63例，化疗栓塞组68例。采用Seldinger方法，将导管超选择插入肿瘤供血动脉：（1）用110℃稀释热碘油脉冲式热栓塞；（2）用碘油化疗药物乳剂栓塞。结果 热栓塞组肿瘤小率和甲胎蛋白（AFP）复常率高于化疗栓塞组，而且术后临床不良反应轻，肝功能损害不明显，生存期较长。结论 高温稀释碘油流动性增加，对肿瘤滋养血管栓塞更为彻底，比热提高，对肿瘤细胞热杀伤作用增强。治疗原发性肝癌疗效好，不良反应轻，适应证广。

Hyperthermal lipiodol embolization and thermocoagulation for the treatment of primary hepatocellular carcinoma

OBJECTIVE: To explore the efficacy of hyperthermal lipiodol embolization and thermocoagulation for the treatment of primary hepatocellular carcinoma. METHODS: One hundred and thirty-one cases were randomized into two groups: the hyperthermal dilute lipiodol embolization group (63 cases) and the chemoembolization group (68 cases). With Seldinger's method, We first placed the catheter to the targeting vessel superselectively and then put the hyperthermal dilute lipiodol (110 degrees C) 10~30ml to the tumor vessels to IV degree for the former group; gave the lipiodol-epirubicin emulsion by the same way to the latter group. RESULTS: The rate of tumor minification and AFP normalization in the hyperthermal lipiodol embolization group was higher than that in the lipiodol-epirubicin embolization group. The side effects and the liver damage were mild in the former group. The survival time of the patients in the former group was longer than that in the latter group. CONCLUSIONS: Embolization of the tumor vessels with hyperthermal dilute lipiodol is more thorough due to its better fluidity. The thermocoagulation of the hyperthermal dilute lipiodol becomes stronger for its higher specific heat. It is therefore a good technique for the treatment of primary hepatocellular carcinoma.