High dose diazepam in schizophrenia |
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Authors: | Helmut Beckmann Steffen Haas |
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Institution: | (1) Department of Psychiatry (M-003), University of California at San Diego, Medical School, 92093 La Jolla, California, USA |
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Abstract: | The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and night-time experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of methylphenidate (25 mg/kg and 50 mg/kg) increased locomotion and sniffing behavior. Flurazepam 3.0 mg/kg augmented methylphenidate-induced stereotyped gnawing behavior and stereotypy. Flurazepam significantly decreased locomotion and sniffing, but did not interact with methylphenidate's effects on locomotion and sniffing. |
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Keywords: | Methylphenidate Flurazepam Stereotyped behavior Dopamine Gnawing behavior Drug interaction |
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