Hormone replacement therapy after treatment for breast cancer: physicians' attitudes towards randomized trials |
| |
| Authors: | Del Giudice M E Sawka C A Pritchard K I Llewellyn-Thomas H A Trudeau M E Lewis J E Franssen E |
| |
| Institution: | (1) Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada;(2) Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada;(3) Department of Medicine, University of Toronto, Toronto, Ontario, Canada;(4) Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada;(5) Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada;(6) Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada;(7) Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada |
| |
| Abstract: | Purpose. Physician support is required for successful patient recruitment to a large randomized controlled trial (RCT) designed to determine the safety and benefits of short-term hormone replacement therapy (HRT) after breast cancer (BC).
Methods. A survey was mailed to 1899 Canadian gynaecologists, family physicians, medical, radiation and surgical oncologists to assess willingness to refer patients to an RCT of HRT after BC.
Results. Of 538 physicians, 420 (78%) reported that they would be willing to refer a woman after BC to an RCT of HRT versus placebo. Variables predicting willingness to refer included: support for HRT in well women (p = 0.04) and after BC (p = 0.0001); support for clinical trials (p = 0.0001); ongoing BC trials at the physicians' institution (p = 0.003); currently prescribing HRT to women after BC (p = 0.03); and beneficial results in ongoing RCTs of HRT in well women (p = 0.02).
Conclusions. An RCT of short-term HRT after BC may be feasible among Canadian physicians. |
| |
| Keywords: | attitudes breast neoplasms hormone replacement therapy physician survey randomized controlled trial |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
