| 细胞因子信号抑制因子1在树突状细胞肿瘤疫苗中的作用 |
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| 引用本文： | 许英艺,陈玉强. 细胞因子信号抑制因子1在树突状细胞肿瘤疫苗中的作用[J]. 国际肿瘤学杂志, 2011, 38(10): 729-732. DOI: 10.3760/cma.j.issn.1673-422X.2011.10.003 |
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| 作者姓名： | 许英艺 陈玉强 |
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| 作者单位： | 福建医科大学教学医院中国人民解放军第174医院肿瘤科,厦门,361003 |
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| 摘 要： | 在肿瘤疫苗中树突状细胞(DC)是启动抗肿瘤免疫的主要辅助细胞.细胞因子信号抑制因子l (SOCS1)对细胞因子信号转导具有抑制作用.最近的研究表明,抑制DC中SOCS1的功能对提高肿瘤疫苗的抗肿瘤活性具有重要作用,并且在如何抑制其功能的方法上也取得了重大进展.
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| 关 键 词： | 树突细胞 癌症疫苗 SOCS1 |
Function of suppressors of cytokine signaling 1 in dendritic cells-based tumor vaccines |
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| XU Ying-yi,CHEN Yu-qiang. Function of suppressors of cytokine signaling 1 in dendritic cells-based tumor vaccines[J]. Journal of International Oncology, 2011, 38(10): 729-732. DOI: 10.3760/cma.j.issn.1673-422X.2011.10.003 |
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| Authors: | XU Ying-yi CHEN Yu-qiang |
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| Abstract: | Dendritic cells (DCs) are the important auxiliary cells in tumor vaccines to activate antitumor immunity.Suppressor of cytokine signaling 1 ( SOCS1 ) has been shown to play an important role in inhibition of cytokine signal transduction.Recent studies show that inhibition of the function of SOCS1 in DCs plays a critical role in strongly enhancing tumor vaccines antitumor activity,and in the methods of restraining SOCS1 's function have also made significant progress. |
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| Keywords: | Dendritic cells Cancer vaccines SOCS1 |
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