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表皮生长因子在肿瘤诊疗中的研究进展
引用本文:李克刚. 表皮生长因子在肿瘤诊疗中的研究进展[J]. 国外医药(抗生素分册), 2011, 0(6): 259-261
作者姓名:李克刚
作者单位:淮安楚州医院,江苏淮安,223200
摘    要:表皮生长因子受体(Epidermal growth factor receptor,EGFR)在90%的肿瘤中存在过度表达。EGFR介导的信号通路与肿瘤细胞扩增、凋亡抑制、血管生成、侵袭及转移有关。EGFR是与细胞增殖有关的蛋白质,而EGFR蛋白表达水平与活性的改变不仅影响细胞的生长亦与细胞对化、放疗的敏感性有关。本文综述TEGFR的结构、功能及其靶向抗肿瘤新生血管生成药物及其研究进展。

关 键 词:表皮生长因子  肿瘤  靶向治疗  纳米金

Progress of Epidermal Growth Factor in Tumor Therapy
Li Ke-gang. Progress of Epidermal Growth Factor in Tumor Therapy[J]. world notes on antibiotics, 2011, 0(6): 259-261
Authors:Li Ke-gang
Affiliation:Li Ke-gang (Huaian Chuzhou Hospital, Huaian Jiangsu 223200 )
Abstract:Epidermal growth factor receptor (EGFR) over expressed in 90% percent of tumors. Signal transduction pathways turned on by EGFR tyrosinekinase (TK) contribute to tumor process such as cellular proliferation, decreased apoptosis, angiogenesis, and invasion and metastasis. EGFR belongs to a family of Proteins involved in the proliferation of normal and malignant cells. The structure, function and physiological effect s of EGFR and the tumor angiogenesis targeting therapy of it's tyrosine kinase receptor (VEGFR) are described respectively in this paper.
Keywords:vascular endothelial growth factor  tumor  targeting therapy  nano-gold
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