组蛋白去乙酰化酶6在非小细胞肺癌组织中的表达及意义

目的 探讨组蛋白去乙酰化酶6 (HDAC6)在非小细胞肺癌(NSCLC)组织中的表达及其临床意义.方法 应用免疫组织化学SP法检测HDAC6在70例NSCLC组织和18例正常肺组织中的表达.结果 在NSCLC组织中HDAC6阳性率为58.57％,显著高于正常肺组织的16.67％ (P ＜0.01)；NSCLC组织中HD...

Expression and significance of histone deacetylase 6 in non-small cell lung cancer

Objective To detect the expression of histone deacetylase 6 (HDAC6) and its significance in non-small cell lung cancer (NSCLC).Methods The expression of HDAC6 was measured by SP staining in 70 cases of NSCLC and 18 cases of normal lung tissues.Results Positive rate of HDAC6 immunostaining in NSCLC was 58.57％,which was significantly higher than 16.67％ in normal lung tissues(P ＜0.01 ).No correlation was found between HDAC6 expression and the age,sex,differentiated level,histological type ( P ＞0.05).But the expression level of HDAC6 was closely related to clinical stage and lymph node metastasis in NSCLC patients ( P ＜ 0.05 ).Conclusion HDAC6 over expression may be related to the pathogenesis and development of NSCLC.