| 干细胞介导溶瘤腺病毒治疗脑胶质瘤研究进展 |
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| 引用本文： | 杨春华,毛立军.干细胞介导溶瘤腺病毒治疗脑胶质瘤研究进展[J].国际肿瘤学杂志,2011,38(11):833-835. |
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| 作者姓名： | 杨春华 毛立军 |
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| 作者单位： | 1. 221000,徐州医学院附属医院放疗科
2. 徐州医学院肿瘤生物治疗实验室 |
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| 基金项目： | 国家自然科学基金，江苏省自然科学基金，江苏省青蓝工程资助项目 |
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| 摘 要： | 溶瘤腺病毒治疗具有肿瘤特异性、安全性和反复表达治疗基因等特点,通过溶瘤腺病毒治疗胶质细胞瘤已获得令人鼓舞的成果,但局部应用溶瘤腺病毒无法作用于散在分布的肿瘤细胞,影响了治疗效果.干细胞对脑胶质瘤具有内在趋化作用,介导溶瘤腺病毒治疗胶质瘤可进一步提高疗效.
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| 关 键 词： | 干细胞 腺病毒科 神经胶质瘤 |
Treatment of malignant gliomas with stem cells mediated oncolytic adenovirus |
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| YANG Chun-hua,MAO Li-jun.Treatment of malignant gliomas with stem cells mediated oncolytic adenovirus[J].Journal of International Oncology,2011,38(11):833-835. |
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| Authors: | YANG Chun-hua MAO Li-jun |
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| Institution: | Department of Radiotherapy, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000,China |
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| Abstract: | Oncolytic adenoviruses are genetically altered to replicate within tumor cella while exhibiting a high degree of infectivity,good safety and specificity.The use of oncolytic adenoviruses to treat malignant brain tumors has been proved to be a promising mode of cancer therapy.Local injection of adenoviral vectors fails to reach scattered infiltrative tumor cells within the brain parenchyma and the therapeutic effect of intracereberal injections of oncolytic adenoviruses is only seen in the vicinity of the injection site.To remedy this and prevent possible tumor recurrence,stem cells have been explored as vehicles for gene therapy in brain tumors given that they possess an intrinsic tropism for brain glioma. |
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| Keywords: | Stem cells Adenoviridae Glioma |
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