| DNA错配修复与肿瘤的发生及治疗 |
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| 引用本文： | 秦丹卿,孟祥宁,白静,傅松滨.DNA错配修复与肿瘤的发生及治疗[J].国际遗传学杂志,2011,34(6). |
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| 作者姓名： | 秦丹卿 孟祥宁 白静 傅松滨 |
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| 作者单位： | 哈尔滨医科大学医学遗传学研究室,150081 |
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| 基金项目： | 973前期专项，国家自然科学基金 |
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| 摘 要： | DNA错配修复系统能够识别和纠正错配的DNA碱基对,确保DNA复制过程的保真性.若是错配修复系统存在缺陷将导致基因突变或基因组不稳定性,最终会导致肿瘤的产生.错配修复系统不仅可以通过修复在DNA复制和重组过程中产生的碱基错配来维持基因组的稳定性,还可以通过识别DNA损伤介导细胞的凋亡,所以细胞的错配修复功能与化疗疗效也有密切相关性.错配修复系统对肿瘤诊断、治疗及预后的重要价值决定了它在肿瘤研究中的重要性.
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| 关 键 词： | DNA错配修复 微卫星不稳定性 治疗敏感性 肿瘤 |
The relationship between DNA mismatch repair system and tumorigenesis and cancer treatment |
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| QIN Dan-qing,MENG Xiang-ning,BAI Jing,FU Song-bin.The relationship between DNA mismatch repair system and tumorigenesis and cancer treatment[J].International JOurnal of Genetics,2011,34(6). |
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| Authors: | QIN Dan-qing MENG Xiang-ning BAI Jing FU Song-bin |
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| Abstract: | The DNA mismatch repair ( MMR ) can recognizes and corrects DNA mismatches to ensure replication fidelity.Defects in MMR are associated with gene mutation or genome instability,which can predispose to certain types of tumors.MMR plays a key role in maintaining genomic stability by correcting mismatches generated during DNA replication and recombination,and also promotes DNA damageinduced apoptosis,so there is a close correlation between MMR function and response to therapy.This review is focused on the importance of MMR status for prognostic,predictive information and response to therapy. |
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| Keywords: | DNA mismatch repair Microsatellite instability Therapeutic sensitivity Tumor |
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