| Hedgehog信号通路与LKB1基因在乳腺癌中的达及其相关性研究 |
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| 引用本文： | 屈雪莹,庄志刚.Hedgehog信号通路与LKB1基因在乳腺癌中的达及其相关性研究[J].国际肿瘤学杂志,2011,38(9):674-676. |
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| 作者姓名： | 屈雪莹 庄志刚 |
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| 作者单位： | 同济大学附属第一妇婴保健院乳腺科,上海,200040 |
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| 摘 要： | Hedgehog信号通路在乳腺癌中过度激活,LKB1是抑癌基因,有抑制乳腺癌增殖的功能.LKB1过表达可调控Hedgehog信号通路的靶基因CyclinD1系列基因的表达,同时研究发现Hedgehog信号通路中PKA基因起重要作用,其激活与cAMP状态有关,而LKB1基因能影响cAMP的状态.因此,LKB1基因与Hed...
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| 关 键 词： | 乳腺肿瘤 信号传导 基因LKB1 |
Expression and correlation of Hedgehog signaling pathway and LKB1 gene in breast cancer |
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| QU Xue ying,ZHUANG Zhi-gang.Expression and correlation of Hedgehog signaling pathway and LKB1 gene in breast cancer[J].Journal of International Oncology,2011,38(9):674-676. |
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| Authors: | QU Xue ying ZHUANG Zhi-gang |
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| Abstract: | Hedgehog signaling pathway is excessive activated in breast cancer.LKBl is currently accepted as a tumor-suppressor gene,which can inhibit the proliferation of breast cancer.The overexpression of LKB1 can regulate the expression of CyclinDl series gene which is a target gene of Hedgehog signaling pathway.Meanwhile,the study found that PKA gene play an important role in Hedgehog signaling pathway,its activation is related with the cAMP state,and LKB1 genes can influence the cAMP state.Therefore,LKB1 gene and the Hedgehog signaling pathway may exist some inevitable connection. |
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| Keywords: | Breast neoplasms Signal transduction Genes LKB1 |
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