| 异种移植免疫排斥的研究进展 |
| |
| 引用本文： | 李俊杰,李霄,窦科峰.异种移植免疫排斥的研究进展[J].国际外科学杂志,2011,38(10):710-714. |
| |
| 作者姓名： | 李俊杰 李霄 窦科峰 |
| |
| 作者单位： | 第四军医大学西京医院肝胆胰脾外科,西安,710032 |
| |
| 摘 要： | 异种移植是解决人体器官严重短缺的重要思路.随着对异种移植排斥和人畜共患感染性疾病的深入研究,以及α-1,3-半乳糖苷转移酶基因敲除猪的成功构建,以猪为供体的异种移植与临床应用之间的距离正在逐渐缩短.阻碍异种移植发展的主要障碍仍是免疫排斥反应.本文试就目前异种免疫排斥的研究进展进行综述,希望对未来的临床异种移植研究提供参...
|
| 关 键 词： | 异种移植 猪 基因修饰 免疫排斥 |
Research progress of immunological rejection in xenotransplantation |
| |
| LI Jun-jie,LI Xiao,DOU Ke-feng.Research progress of immunological rejection in xenotransplantation[J].International Journal of Surgery,2011,38(10):710-714. |
| |
| Authors: | LI Jun-jie LI Xiao DOU Ke-feng |
| |
| Abstract: | Xenotransplantation can probably overcome the critical shortage of human organ donors for clinical transplantation.Recently,research progresses in the biology of xenograft rejection and zoonotic infections,and the generation of α1,3-galactosyltransferase-deficient pigs have moved this approach closer to clinical application,but immunological rejection is also the primary barrier in the study of xenotransplantation.This review sumarries the research progress of immunological rejection of xenotransplantation,providing some advices for the future of clinical xenotransplantation. |
| |
| Keywords: | Xenotransplantaion pig Genetical modification Immunological rejection |
| 本文献已被 万方数据 等数据库收录！ |
|
