肿瘤坏死因子相关凋亡诱导配体与胰腺癌及相关药物研究

自肿瘤坏死因子家族的新成员肿瘤坏死因子相关凋亡诱导配体被发现以来,它一直是近些年来在肿瘤研究方面的热点.本文综述了近些年肿瘤坏死因子相关凋亡诱导配体在胰腺癌方面的相关研究进展,从肿瘤坏死因子相关凋亡诱导配体诱导胰腺癌肿瘤细胞凋亡机制人手,简要介绍胰腺癌对肿瘤坏死因子相关凋亡诱导配体的耐药机制.并根据目前已认同的耐药机制...

Synergistic cytotoxic effects of tumor necrosis factor-related apoptosis-inducing ligand combined with valid drugs on panreatic carcinoma

Since the tumor necrosis factor-related apoptosis-inducing ligand was found as a suitable agent for anticancer therapies,study on tumor research has been attaching more importance to it.Utilized the progress on the study of TRAIL on pancreatic carcinoma aspect recent years and standed the principle in TRAIL inducing pancreatic carcinoma apoptosis,this article first simply reviewed the resistance theory of TRAIL on pancreatic carcinoma.Following the trail of identified resistance theory,carring the method of increasing TRAIL's sensibility with protein inhibition,signal regulation,ect,some new treatments have been received,which are described along with the antitumor effect of TRAIL combined with mature treatment in pancreatic carcinoma,and simply assessed at last in the article,to provide a reference on the synergistic cytotoxic effects of TRAIL combined with valid drugs on panreatic carcinoma.