| 巨噬细胞游走抑制因子在肿瘤中的作用 |
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| 引用本文： | 张宏波,刘锦. 巨噬细胞游走抑制因子在肿瘤中的作用[J]. 国际肿瘤学杂志, 2011, 38(10): 741-744. DOI: 10.3760/cma.j.issn.1673-422X.2011.10.007 |
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| 作者姓名： | 张宏波 刘锦 |
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| 作者单位： | 450001,郑州大学基础医学院解剖学教研室 |
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| 摘 要： | 巨噬细胞游走抑制因子(MIF)是一种独特的促进肿瘤发生的细胞因子,可直接参与癌基因诱导的恶性转化并调节细胞的分裂,也可间接通过抑制肿瘤细胞凋亡、促进肿瘤侵袭及血管生成等多方面作用影响肿瘤的发生发展.针对MIF的肿瘤生物靶向治疗可能成为肿瘤治疗的新途径.
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| 关 键 词： | 巨噬细胞游走抑制因子 肿瘤 细胞凋亡 肿瘤侵润 |
Role of macrophage migration-inhibitory factor in cancer |
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| ZHANG Hong-bo,LIU Jin. Role of macrophage migration-inhibitory factor in cancer[J]. Journal of International Oncology, 2011, 38(10): 741-744. DOI: 10.3760/cma.j.issn.1673-422X.2011.10.007 |
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| Authors: | ZHANG Hong-bo LIU Jin |
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| Affiliation: | Department of Anatomy,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China |
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| Abstract: | Macrophage migration-inhibitory factor (MIF) is a cytokine which can promote tumorigenesis.MIF can promote tumorigenesis by directly inducing oncogene transformation,stimulating cell division,as well as indirectly inhibiting tumor apoptosis,promoting its invasiveness and angiogenesis.MIF-targeted biological therapy may become a new therapeutic strategy for malignant tumor. |
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| Keywords: | Macrophage migration-inhibitory factors Neoplasms apoptosis Neoplasm invasiveness |
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