| 大肠杆菌不耐热肠毒素B亚单位研究进展 |
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| 引用本文： | 单璞. 大肠杆菌不耐热肠毒素B亚单位研究进展[J]. 国际生物制品学杂志, 2011, 34(5): 262-266. DOI: 10.3760/cma.j.iaan.1673-4211.2011.05.008 |
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| 作者姓名： | 单璞 |
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| 作者单位： | 100024,北京生物制品研究所免疫研究室 |
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| 摘 要： | 不耐热肠毒素B亚单位(heat-labile enterotoxin B subunit,LTB)是产肠毒素性大肠杆菌分泌到细胞周质的肠毒素的组成部分,具有黏膜免疫佐剂活性,可介导细菌与肠上皮细胞结合.此文对LTB的结构、重组表达、作为黏膜佐剂的免疫学评价和作用机制等方面进行综述.
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| 关 键 词： | 肠毒素类 免疫,黏膜 佐剂,免疫 |
Research progress in heat-labile enterotoxin B subunit of Escherichia coli |
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| SHAN Pu. Research progress in heat-labile enterotoxin B subunit of Escherichia coli[J]. International Journal of Biologicals, 2011, 34(5): 262-266. DOI: 10.3760/cma.j.iaan.1673-4211.2011.05.008 |
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| Authors: | SHAN Pu |
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| Abstract: | Heat-labile enterotoxin B subunit (LTB) is a part of enterotoxin secreted into cellular periplasm by enterotoxigenic Escherichia coli (ETEC).LTB has mucosal immunoadjuvant activity,and can mediate ETEC binding to intestinal epithelium cells.This paper summarizes structure,recombination expression,immunity evaluation as mucosal adjuvant and effect mechanism of LTB. |
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| Keywords: | Enterotoxins Immunity,mucosal Adjuvants,immunologic |
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