| 氩氦刀治疗恶性黑色素瘤对小鼠T细胞免疫的影响 |
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| 引用本文： | 骆益宙,钱建新,顾小强,于观贞,王战,武清,王杰军. 氩氦刀治疗恶性黑色素瘤对小鼠T细胞免疫的影响[J]. 华南国防医学杂志, 2008, 22(1): 7-8 |
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| 作者姓名： | 骆益宙 钱建新 顾小强 于观贞 王战 武清 王杰军 |
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| 作者单位： | 解放军454医院肿瘤科,南京,210002;上海长征医院肿瘤科 |
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| 基金项目： | 南京军区医药卫生科研项目 |
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| 摘 要： | 目的 研究氩氦刀治疗小鼠恶性黑色素瘤后激活特异性T淋巴细胞的免疫效应。方法12只C57／BL小鼠分3组，A组4只接种B16恶性黑色素瘤细胞，并行氩氦刀治疗；B组4只建立荷瘤模型；C组4只为对照。利用混合淋巴细胞反应检测特异性细胞毒性T淋巴细胞的增殖。结果氩氦刀治疗后可显著刺激特异性T淋巴细胞增殖，与对照组比较具有显著性差异（P〈O．01）。结论氩氦刀治疗可有效激活小鼠肿瘤抗原特异性的T细胞。
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| 关 键 词： | 恶性黑色素瘤 氦刀 T细胞免疫 |
| 收稿时间： | 2007-11-02 |
| 修稿时间： | 2007-11-20 |
Effect of Cryosurgery on Function of T Cellular Immunity in Mice with Malignant Melanoma Carcinoma |
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| LUO Yi-zhou, QIAN J ian-xin , GU Xiao-qiang ,. Effect of Cryosurgery on Function of T Cellular Immunity in Mice with Malignant Melanoma Carcinoma[J]. Military Medical Journal of South China, 2008, 22(1): 7-8 |
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| Authors: | LUO Yi-zhou QIAN J ian-xin GU Xiao-qiang |
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| Affiliation: | LUO Yi-zhou, QIAN J ian-xin , GU Xiao-qiang , (et al. Department of Oncology , No. 454 Hospital of PLA , Nan- jing Jiangsu 220002, China) |
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| Abstract: | Objective To study the effect of cryosurgery on activating T ell immunity in mice with malignant melanoma carcinoma. Methods Twelve C57/BL mice were randomly divided into group A （the mice were transplanted with B16 malignant melanoma cells, then treated by cryosurgery）, group B （only transplanted with B16 cells）and group C as control. The proliferative activities of cytotoxic T lymphocytes were investigated by using mixed lymphocytes reaction. Results After cryosurgery, the cytotoxic T lymphocytes were activated into proliferate effectively. The proliferation rate of cytotoxic T lymphocytes in group A was significantly higher than that in group C （P〈O. 01）. Conclusion Cryosurgery can effectively activate tumor antigen-specific T lymphocytes. |
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| Keywords: | Malignant melanoma Crvosurgerv T cell immunity |
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