| 老年期抑郁症病人听觉事件相关电位P300的比较研究 |
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| 引用本文： | 吕永良,吴爱勤,李鸣,刘建农. 老年期抑郁症病人听觉事件相关电位P300的比较研究[J]. 四川精神卫生, 2004, 17(1): 17-19 |
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| 作者姓名： | 吕永良 吴爱勤 李鸣 刘建农 |
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| 作者单位： | 1. 215008,江苏省苏州市广济医院
2. 苏州大学附属第一医院精神科 |
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| 基金项目： | 苏州市 2 0 0 2年度第一批指导性科技 (社会发展 )项目(SSZ0 2 2 7) |
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| 摘 要： | 目的 探讨老年期抑郁症病人的认知功能状况。方法 按CCMD-3中心境障碍抑郁发作诊断标准，收集33例60岁以上首次抑郁发作的病人(抑郁组)，32名健康老年人(对照组)。使用HAMD、HAMA和MMSE量表对所有入组者进行评定，并作P300测定。结果 抑郁组MMSE总分低于对照组。抑郁组N2和P3潜伏期比对照组延长；抑郁组的P300潜伏期N2和P3与HAMD的迟缓因子分呈正相关，与MMSE总分呈负相关。结论 老年期抑郁症病人存在认知功能障碍。
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| 关 键 词： | 老年期抑郁症 认知功能 事件相关电位 |
| 文章编号： | 1007-3256(2004)01-0017-03 |
The comparative study of P300 among elderly depressed patients and elderly healthy people |
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| LU Yongliang,WU Aiqin,LI Ming,et al.. The comparative study of P300 among elderly depressed patients and elderly healthy people[J]. Sichuan Mental Health, 2004, 17(1): 17-19 |
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| Authors: | LU Yongliang WU Aiqin LI Ming et al. |
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| Affiliation: | LU Yongliang,WU Aiqin,LI Ming,et al.Suzhou Guangji Hospital,Jiangsu 215008,China |
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| Abstract: | Objective To explore cognitive function in elderly depressed patients.Methods 33 elderly people(aged over 60)(depression group) with the first episode of depression diagnosed according to CCMD-3 and elderly healthy people (aged over 60)(control group) were investigated.All subjects were interviewed in semi-structured manner with common data and case history questionnaire,HAMD,HAMA,MMSE,and measured event-related potentials.Results The score of MMSE was significantly lower in depression group than in control group.N2 and P3 latency in depression group were significantly longer than those in control group.In elderly depressed patients,N2 and P3 latency were positively related to psychomotor retardation item of HAMD,but negatively related to score of MMSE.Conclusion Elderly depressed patients have cognitive dysfunction. |
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| Keywords: | Elderly depressed patient Cognitive function Event-related potential P300 |
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