亚甲基四氢叶酸还原酶基因C677T多态性与精神分裂症关系的Meta分析

目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T位点多态性与精神分裂症易感性的关系。方法检索精神分裂症组和对照组MTHFR基因C677T位点多态性的优势比(OR)值或相对危险度(RR)值为效应指标的相关文献,对符合入选标准的文献,应用RevMan 5.0软件对各研究结果进行异质性检验和效应值合并,并进行敏感性分析和偏倚评估。结果纳入MTHFR基因C677T位点多态性文献11篇,共计病例5 719例,其中,精神分裂症组2 630例,对照组3 089例,各研究异质性检验(P<0.05),采用随机效应模型,第677位点CT、TT、CT+TT基因型的合并OR值(95%CI)分别为1.20(0.99～1.46)、1.58(1.09～2.29)、1.28(1.03～1.59),Z值分别为1.86、2.44、2.27,P值分别为0.06、0.01、0.02。除CT基因型的敏感性分析不稳定外,其他两型稳定。3种基因型的漏斗图形均对称。结论 MTHFR基因677TT、CT+TT基因型为精神分裂症发生的危险因素。

Meta-analysis of relationship between C677T genetic polymorphism in methylenetetrahydrofolate reductase and schizophrenia

Objective To investigate the relationship between 5,10-methylenetetrahydrofolate reductase(MTHFR) C677T gene polymorphisms and susceptibility to schizophrenia.Methods The entry criteria were based on by searching and reviewing the literatures involved in MTHER C677T and schizophrenia and calculating the pooled Or or RR,and the literatures eligible were studied by checking the heterogeneity and evaluating the publication bias and sensitivity by software of RevMan5.0.Results The 11 studies involved in MTHFR C677T gene polymorphism and schizophrenia consisted of 2630 cases and 3089 cases of control,with heterogeneity test by random effect model shown(P<0.05).The pooled OR of CT vs.CC,TT vs.CC,CT+TT vs.CC were1.20(0.99-1.46),1.58(1.09-2.29),1.28(1.03-1.59).The sensitiveness analysis of CT was instable,but CT and CT+TT was stable.The publication bias examined by graph of the funnel plot showed no significance.Conclusion MTHFR 677 CT and CT+TT gene polymorphisms can increase the risk factors of schizophrenia development.