70例非小细胞肺癌表皮生长因子受体的检测分析

目的探讨表皮生长因子受体(EGFR)在非小细胞肺癌(NSCLC)中的表达特征及其临床病理意义。方法采用免疫组化染色Envision法检测EGFR在70例NSCLC中和12例健康肺组织中的表达。结果在70例NSCLC患者中,EGFR高表达率为72.9%,与健康肺组织比较差异有统计学意义(P<0.05),EGFR高表达与年龄、性别、肿瘤大小、组织学类型及病理分级间无关(P>0.05),与TNM分期、淋巴结转移显著相关(P<0.05),且其表达水平与TNM分期及淋巴结转移呈正相关。结论 (1)EGFR蛋白过表达与NSCLC的发生有密切关系;(2)EGFR蛋白过表达与NSCLC患者TNM分期及淋巴结转移相关,说明其过表达与肺癌的进展、转移有关。

Study on expression and significance of epidermal growth factor receptor in 70 cases with non-small cell lung cancer

Objective To explore the expressional characteristics and clinicopathologic significance of epidermal growth factor receptor(EGFR) in non-small cell lung cancer(NSCLC).Methods Expression of EGFR in 70 cases with NSCLC and 12 normal lung tissues was measured by Immunohistochemical Envision method.Results The high expression rate was 72.9% in NSCLC cases,significantly higher than that in normal lung specimens(P<0.05).Some of the clinic alparameters(age,sex,tumour size,histological type,and pathological grade) had no influence on high experssion rate of EGFR cases(P>0.05).But TNM stage and lymphnode metastasis had significant positive correlation with high expression of EGFR(P<0.05).Conclusion(1)The high expression of EGFR was associated with the occurrence of NSCLC.(2)The high experssion of EGFR was significantly related to TNM stage and lymph nodal metastasis in patients with NSCLC,which showed that their levels of expression were correlated with the development and metastasis of NSCLC.