丁苯酞对血管性痴呆患者认知功能的改善作用

目的 观察丁苯酞软胶囊治疗轻、中度血管性痴呆(VaD)的临床疗效和安全性.方法 62例轻、中度VaD患者随机分为2组:治疗组31例,给予丁苯酞软胶囊0.2克/次,口服,3次/天;对照组31例,给予维生素E软胶囊 0.1克/次,口服,3次/天;两组总疗程为12周.分别于治疗前和治疗后4、8、12周进行认知功能测定,采用简...

Improving effect of butylphthalide on cognition in patients with vascular dementia

Objective To observe the efficacy and safety of butylphthalide in the treatment of mild to moderate vascular dementia(VaD).Methods Sixty-two patients with mild to moderate VaD were randomly divided into 2 groups: the butylphthalide treatment group(n=31) and the control group(n=31).The participants received either vitamin E capsule(0.1 g,t.i.d.) as control or butylphthalide capsule(0.2 g,t.i.d.) for 12 consecutive weeks.The Mini-Mental State Examination(MMSE),Clinical Dementia Rating(CDR),and Activities of Daily Living(ADL) scores were used for the assessment of cognition.The assessments were done prior to treatment,and in 4,8,and 12 weeks after treatment.The adverse effects of butylphthalide were also recorded.Detections were made to observe the changes of creatine(Cr),blood urea nitrogen(BUN),glutamic-oxalacetic transminase(GOT) and glutamic-pyruvic transminase(GPT).Results After 12 weeks of treatment,the MMSE,CDR,and ADL scores were significantly improved in the butylphthalide group(P<0.01 for all comparisons),whereas the control group did not show any improvement(P>0.05 for all comparisons).No serious adverse events were recorded during treatment.Conclusion Butylphthalide can prominently improve the cognitive function of the patients with mild to moderate vascular dementia.Morever,its security and tolerability are good.