| 重庆地区绝经妇女骨质疏松症与维生素D受体基因多态性的关系 |
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| 引用本文： | 陈隽,张莉萍,邱君凤,彭辉,邓忠良,王玉君,严钟德. 重庆地区绝经妇女骨质疏松症与维生素D受体基因多态性的关系[J]. 中华医学遗传学杂志, 2003, 20(2): 167-168 |
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| 作者姓名： | 陈隽 张莉萍 邱君凤 彭辉 邓忠良 王玉君 严钟德 |
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| 作者单位： | 400010,重庆医科大学第二附属医院内分泌科 |
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| 基金项目： | 重庆市教委项目 ([1 999] 1 6)~~ |
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| 摘 要： | 目的：探讨在重庆市区生活10年以上的汉族绝经妇女骨质疏松症与维生素D受体基因多态性的关系。方法：用聚合酶链反应－限制性片段长度多态性技术检测了40例绝经后患骨质疏松症的妇女和21名同龄绝经后无骨质疏松症的妇女的维生素D受体基因多态性。结果：骨质疏松组维生素D受体基因型bb、Bb、BB频率分别为82．5％、17．5％及0，无骨质疏松组分别为85．71％、14．29％及0，两组差异无显著性（P＞0．05）。结论：就目前调查例数看，重庆地区汉族妇女骨质疏松与BB基因型无明显相关性。
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| 关 键 词： | 绝经 骨质疏松 维生素D受体 基因型 聚合酶链反应 |
| 修稿时间： | 2002-01-28 |
Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women |
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| CHEN Jun,ZHANG Li ping,QIU Jun feng,PENG Hui,DENG Zhong liang,WANG Yu jun,YAN Zhong de.. Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women[J]. Chinese journal of medical genetics, 2003, 20(2): 167-168 |
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| Authors: | CHEN Jun ZHANG Li ping QIU Jun feng PENG Hui DENG Zhong liang WANG Yu jun YAN Zhong de. |
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| Affiliation: | Department of Endocrinology, the Second Teaching Hospital of Chongqing Medical University, Chongqing, 400010 P. R. China. Chen_96938@163.com |
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| Abstract: | Objective To determine the relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis in postmenopausal women.Methods The polymerase chain reaction restriction fragment length polymorphism was used to detect VDR genotype in 40 patients with osteoporosis and 21 healthy postmenopausal women.Results In the patients with osteoporosis, the bb, Bb, and BB genotype accounted for 82.5%, 17.5% and 0, respectively; in healthy groups, they were 85.71%, 14 29% and 0, respectively( P>0.05). Conclusion Significant association between VDR genotype and osteoporosis in Chinese women was observed in this study. |
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| Keywords: | postmenopausal osteoporosis vitamin D receptor genotype polymerase chain reaction |
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