| 胃炎消对麻醉大鼠基础泌酸及胃泌素诱导泌酸的影响 |
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| 引用本文： | 杜群,吴秀美,王汝俊. 胃炎消对麻醉大鼠基础泌酸及胃泌素诱导泌酸的影响[J]. 中药新药与临床药理, 2004, 15(1): 12-14 |
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| 作者姓名： | 杜群 吴秀美 王汝俊 |
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| 作者单位： | 1. 广州中医药大学脾胃研究所,广州,510405
2. 广州中医药大学第一附属医院,广州,510405 |
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| 摘 要： | 目的观察胃炎消对麻醉大鼠胃酸分泌的影响.方法采用麻醉大鼠活体胃灌流模型,用精密酸度计测量灌流液pH值,观察胃炎消对基础泌酸及胃泌素诱导泌酸的影响.结果胃炎消小剂量(12.3g生药/kg)对基础泌酸无明显影响(P>0.05),大剂量(24.6g生药/kg)能明显抑制基础胃酸分泌(P<0.05);胃炎消小剂量(12.3g生药/kg)对胃泌素诱导的高胃酸分泌水平有轻度抑制作用,大剂量(24.6g生药/kg)则对其有明显的抑制作用(P<0.01).结论胃炎消对麻醉大鼠胃酸分泌有抑制作用,这可能是其抗溃疡及抗急性胃粘膜损伤的药理作用机理之一.
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| 关 键 词： | 胃炎消 胃酸分泌 胃泌素 |
| 文章编号： | 1003-9783(2004)01-0012-03 |
| 修稿时间： | 2003-08-10 |
Effects of Weiyanxiao on Basal Gastric-acid Secretion and Gastrin-induced Gastric-acid Secretion in Anesthetized Rats |
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| DU Qun,WU Xiumei,WANG Rujun. Effects of Weiyanxiao on Basal Gastric-acid Secretion and Gastrin-induced Gastric-acid Secretion in Anesthetized Rats[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2004, 15(1): 12-14 |
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| Authors: | DU Qun WU Xiumei WANG Rujun |
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| Affiliation: | DU Qun1,WU Xiumei2,WANG Rujun1 |
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| Abstract: | Objective Effects of Weiyanxiao on basal gastric- acid secretion in anesthetized rats were investigated.Methods pH value of gastric perfusate in rat models of gastric perfusion were detected with a precise acidity meter to evaluated the effects of Weiyanxiao on basal gastric- acid secretion and gastrin- induced acid secretion.Results Small- dose Weiyanxiao (12.3 g/kg) had no significant influence on basal gastric- acid secretion and has slight inhibition on high- level gastric- acid secretion induced by gastrin ;large- dose Weiyanxiao (24.6g/kg) could restrain basal gastric- acid secretion (P < 0.05) and high- level gastric- acid secretion induced by gastrin (P < 0.01).Conclusion Weiyanxiao can restrain the secretion of gastric acid in anesthetized rats,which may be one of the pharmacological mechanisms in counteracti ng ulcer and acute lesion of gastric mucosa. |
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| Keywords: | Weiyanxiao Gastric acid secretion Gastrin |
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