| 皮肌炎并发恶性肿瘤患者P53蛋白表达的研究 |
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| 引用本文： | 张士发,梁再赋,许静,冯永山,赵丽萍,王良明,刘宝军,顾绍裘.皮肌炎并发恶性肿瘤患者P53蛋白表达的研究[J].中国麻风皮肤病杂志,2003,19(2):104-105. |
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| 作者姓名： | 张士发 梁再赋 许静 冯永山 赵丽萍 王良明 刘宝军 顾绍裘 |
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| 作者单位： | 1. 沈阳军区总医院皮肤科,沈阳,110016
2. 中国医科大学,沈阳 |
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| 摘 要： | 目的：探讨P53蛋白在皮肌炎并发恶性肿瘤过程中的作用。方法：应用免疫组化技术对皮肌炎患者的肿瘤组织细胞及外周血单个核细胞(PBMCs)P53蛋白的表达进行了检测。结果：1例皮肌炎并发卵巢癌患者的肿瘤细胞及PBMCs均表达P53蛋白，另1例皮肌炎并发鼻咽癌患者的肿瘤细胞、浸润单个核细胞及PBMCs均表达P53蛋白。其它15例未并发恶性肿瘤的皮肌炎患者中有1例PBMCs表达P53蛋白。20例正常对照均阴性。结论：p53基因的种系突变在皮肌炎并发恶性肿瘤中可发能发挥重要作用。
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| 关 键 词： | 皮肌炎 并发症 恶性肿瘤 P53蛋白 核细胞 肿瘤细胞 卵巢癌 鼻咽癌 |
Expression of P53 protein in patients with dermatomyositis accompanying malignant tumors |
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| Zhang Shifa,Liang Zaifu,Xu Jing,et al..Expression of P53 protein in patients with dermatomyositis accompanying malignant tumors[J].China Journal of Leprosy and Skin Diseases,2003,19(2):104-105. |
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| Authors: | Zhang Shifa Liang Zaifu Xu Jing |
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| Institution: | Zhang Shifa,Liang Zaifu,Xu Jing,et al. Department of Dermatology,General Hospital of Shenyang Military Region,Shenyang,110001 |
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| Abstract: | Objective:To explore the role of P53 protein in the pathogenesis of dermatomyositis accompanying malignant tumors. Method: P53 protein expression in patients with dermatomyositis was measured with immunohistochemical assay. Results: The tumor cells and peripheral mononuclear cells (PBMCs) expressed P53 protein in the patients with dermatomyositis accompanying ovarian and nasopharyngeal carcinoma. PBMCs in one of 15 cases of dermatomyositis without accompanying malignant tumors expressed P53 protein. All 20 normal controls P53 protein were negative. Conclusion :The germ line mutation of P53 gene may play an important role in the pathogenesis of dermatomyositis with malignant tumors. |
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| Keywords: | dermatomyositis tumor P53 protein |
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