| 胃癌细胞多药耐药机制及耐药性逆转 |
| |
| 引用本文： | 郝淑兰,刘丽坤,李宜放.胃癌细胞多药耐药机制及耐药性逆转[J].肿瘤研究与临床,2007,19(1):68-70,72. |
| |
| 作者姓名： | 郝淑兰 刘丽坤 李宜放 |
| |
| 作者单位： | 030012,太原,山西省中医药研究院肿瘤科 |
| |
| 摘 要： | 中国胃癌的发病例数占全球总数的1／3。化疗是治疗胃癌的有效手段，但由于肿瘤细胞多药耐药性（MDR）的产生，化疗疗效往往不佳。深入探讨胃癌MDR产生机制，寻找有效低毒的多药耐药逆转剂，对提高化疗的有效性，延长患者的生存期有着重要的意义。从转运蛋白有关的耐药机制、酶系统有关的耐药机制、细胞凋亡与耐药、细胞因子等四方面肿瘤细胞MDR产生的机制做一简要综述。
|
| 关 键 词： | 胃肿瘤 抗药性 多药 多药耐药相关蛋白质类 反转录酶抑制剂 |
| 文章编号： | 1006-9801（2007）01-0068-04 |
| 收稿时间： | 2006-08-23 |
| 修稿时间： | 2006-08-232006-12-09 |
Multidrug resistance mechanisms and reversal agents in gastric carcinoma cells |
| |
| HAO Shu-lan,LIU Li-kun,LI Yi-fang.Multidrug resistance mechanisms and reversal agents in gastric carcinoma cells[J].Cancer Research and Clinic,2007,19(1):68-70,72. |
| |
| Authors: | HAO Shu-lan LIU Li-kun LI Yi-fang |
| |
| Institution: | Department of Oncology, Shanxi Academy of traditional Chinese Medicine and Pharmacy, Taiyuan 030012, China |
| |
| Abstract: | The incidence of gastric carcinoma in our country has objected to one-third in all globe. The effective means to treat gastric carcinoma is chemical theraty,but because of production of tumor cells muhidrug resistance,effection of chemical therapy is not very good.Explore gastric carcinoma MDR mecha- nism,find low poison and highly efficient MDR reversal agents have more important significance for improving chemical therapeutic effectiveness,prolonging sickness survival time.Now,four mechanisms about tumor cells multidrug resistance are summaried such as transport protein,enzyme system,programmed cell death and cy- tokine. |
| |
| Keywords: | Gastric cancer Drug resistance Multiple Multidrug resistance-Associated proteins Reverse transcripase inhibitors |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《肿瘤研究与临床》浏览原始摘要信息 |
| 点击此处可从《肿瘤研究与临床》下载免费的PDF全文 |
