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CD4CD25 regulatory T cell in childhood ocular myasthenia gravis
Authors:Hiroshi Sakuma  Ayako Katayama  Yoshiaki SaitoHirofumi Komaki  Eiji NakagawaKenji Sugai  Masayuki Sasaki
Institution:a Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan
b Department of Pediatrics, Shimada Center for Rehabilitation and Neurodevelopmental Intervention, Tokyo, Japan
Abstract:Dysfunction of CD4+CD25+ regulatory T cell (Treg) has been demonstrated to play an important role in the development of autoimmune myasthenia gravis. This T cell subset, which has potent regulatory properties against immune response, has been reported to have a numerical or functional defect in patients with myasthenia gravis. We examined various T cell subsets, including CD4+CD25+Treg in peripheral blood mononuclear cells using flow cytometry in a pediatric patient suffering from ocular myasthenia gravis. Contrary to previous reports, the percentage of CD4+CD25+Treg in peripheral blood decreased significantly after successful treatment with prednisolone. This discrepancy could result from diversity within the immunopathogenesis of myasthenia gravis and may underpin a particular subgroup of myasthenia gravis seen in the East-Asian pediatric population.
Keywords:Myasthenia gravis  Childhood  Ocular  Regulatory T cell  Corticosteroid
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