| 谷氨酸对大鼠海马CA1区锥体细胞电压依赖性Na^＋电流的影响 |
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| 引用本文： | 许长庆 吴才宏. 谷氨酸对大鼠海马CA1区锥体细胞电压依赖性Na^＋电流的影响[J]. 基础医学与临床, 2000, 20(2): 78-79 |
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| 作者姓名： | 许长庆 吴才宏 |
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| 作者单位： | 广东江门市中心医院神经内科!江门529071(许长庆)，北京医科大学附属三院外科(张宗明)，北京大学生物膜与膜生物工程国家重点实验室!北京100083(吴才宏，周培爱) |
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| 基金项目： | 山东省自然科学青年基金!No．Q95C0925 |
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| 摘 要： | 本实验采用全细胞膜片钳技术、观察了谷氨酸对急性分离的海马ＣＡ１区神经元的电压依赖性Ｎａ＾＋通道的影响，结果发现谷氨酸对电压依赖性Ｎａ＾＋电流有明显抑制作用，其抑制方式呈电压依赖性，浓度依赖性和时间依赖性，表明谷氨酸对电压依赖性钠通道有抑制作用。
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| 关 键 词： | 谷氨酸 海马 钠电流 CA1区 锥体细胞 |
Effect of glutamate on voltage-dependent Na~ currents of acutely dissociated Hippocampal CA_1 pyramidal cells in rat |
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| XU Chang-qing,ZHANG Zong-ming,WU Cai-hong. Effect of glutamate on voltage-dependent Na~ currents of acutely dissociated Hippocampal CA_1 pyramidal cells in rat[J]. Basic Medical Sciences and Clinics, 2000, 20(2): 78-79 |
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| Authors: | XU Chang-qing ZHANG Zong-ming WU Cai-hong |
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| Abstract: | The effect of glutamate on voltge-dependent Na~ current in acutely isolated hippocampal CA_1 pyramidal neurons of postnatal rats (7~ 10days ) were studied by means of the whole cell recording patch clamp technique. The results realed that glutamate induced an apparent blockage of INa. Its blockage on INa has voltage-dependent, dose-dependent and timedependent characteristics. These results suggested that glutamate can inhibit voltage-dependent Na~ Channel. |
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| Keywords: | glutamate: hippocampus sodium current |
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