| G-CSF、GM-CSF的临床应用现状 |
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| 引用本文： | 童英,苏文英,杨琳.G-CSF、GM-CSF的临床应用现状[J].基础医学与临床,2000,20(2):5-8. |
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| 作者姓名： | 童英 苏文英 杨琳 |
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| 作者单位： | 中国人民解放军空军总医院妇产科!北京100036(童英，杨琳)，河北省保定市第二医院妇产科!保定071000(苏文英) |
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| 摘 要： | 粒细胞集落刺激因子（Ｇｒａｎｕｌｏｃｙｔｅ ｃｏｌｏｎｙ－ｓｔｉｍｕｌａｔｉｎｇ ｆａｃｔｏｒ， Ｇ－ＣＳＦ）、粒巨噬细胞集落刺激因子（ Ｇｒａｎｕｌｏｃｙｔｅ ｍａｃｒｏｐｈａｇｅ ｃｏｌｏｎｙ－ｓｔｉｍｕｌａｔｉｎｇ ｆａｃｔｏｒ，ＧＭ－ＣＳＦ）分别是促粒系、粒－单系造血祖细胞增殖、分化及成熟，并增强其成熟细胞功能的特异造血调控生长因子。重组ＤＮＡ技术的发展，使得利用基因工程方法大量生产细胞因子成为可能。目前，Ｇ－ＣＳＦ、ＧＭ－ＣＳＦ基因重组产品已广泛应用于临床。在血液病的治疗，造血干细胞移植及恶…
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| 关 键 词： | G－CSF GM－CSF 集落刺激因子 临床应用 |
Clinical application of G-GSF and GM-CSF |
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| TONG Ying,et al.Clinical application of G-GSF and GM-CSF[J].Basic Medical Sciences and Clinics,2000,20(2):5-8. |
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| Authors: | TONG Ying |
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| Abstract: | Granulocyte colony-stimulating factor (G-CSF ), granulocyte-microphage colony-stimulating factor (GM- CSF ) is specific hematopoietic regulating growth factor of granulocyte lineage, granulocyte-monocyte lineage, respectively. G-CSF. GM-CSF can promote the proliferation, differentiation and mature of its hematopoietic progenitor and enhance the function of mature blood cell. Their gene recombinant human products have been widely applied to clinical practice. The effects of G-GSF. GM-CSF in clinical application are as follows (l ) reducing malignant tumor chemotherapy-related neutropenia, duration of neutropenia, infections and resulting treatment delays. (2 ) mobilizing peripheral blood stem progenitor cell and speeding hematopoietic reconstituation following allogeneic and autologous stem progenitor transplantation. The recent clinical application of G-CSF. GM-CSF has been summarized in this review. |
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| Keywords: | G-CSF GM-CSF clinical application |
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