心肌肥大的信号转导机制

编者按：细胞信号转导在当今生命科学领域占有极其重要的地位，自20世纪90年代以来，与细胞信号转导有关的研究已两度获诺贝尔医学奖，由此可见一斑。以此为契机，探索疾病的信号转导机制已成为当前国际上倍受瞩目的热点课题。心肌肥大和心力衰竭是大多数心血管疾病的严重或终末阶段，研究其细胞信号转导机制改变及其在发病学中的作用具有非常重要的意义。本专题重点介绍目前这一领域的研究进展，内容涉及心肌肥大和心力衰竭时细胞内信号转导通路的改变、心力衰竭时肾上腺素受体及其信号转导机制的改变等方面。尤其值得一提的是，本专题还包…

Cellular signal transduction in cardiac hypertrophy

Cardiac hypertrophy is a fundamental response of cardiac myocytes to various stimuli such as mechanical overload,humoral factors and genetic mutations in cardiac contractile protein genes. Beside an increase in cell size and alteration in cellfunction, the reprograming of gene expression is its essential mechanism and cellular signal transduction is the important linkof external stimuli to nucleous reaction. At present, cellular signal transduction pathways in cardiac hypeytrophy are intenselystuding and have made much progress. In the article, the advances in studing on signal transduction ofcardiac hypertrophy weresummerized.